Diagnostic and prognostic utility of C-reactive protein, alpha-1-antitrypsin and alpha-2-macroglobulin in neonatal sepsis: a comparative account.

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dc.contributor.authorSuri, Men_US
dc.contributor.authorThirupuram, Sen_US
dc.contributor.authorSharma, V Ken_US
dc.date.accessioned1991-10-01en_US
dc.date.accessioned2009-05-27T06:07:45Z
dc.date.available1991-10-01en_US
dc.date.available2009-05-27T06:07:45Z
dc.date.issued1991-10-01en_US
dc.description.abstractC-reactive protein (CRP), alpha-1-antitrypsin (alpha-1-AT) and alpha-2-macroglobulin (alpha-2-MG) levels were evaluated serially in 25 healthy and 20 septicemic neonates and then compared as early diagnostic aids and prognostic indicators in this illness. Compared to healthy controls, septicemic neonates had significantly higher mean CRP levels (p less than 0.01). Neonates with septicemia, who recovered, had higher mean CRP levels than the group which died (p less than 0.05). As an early diagnostic aid CRP had a low Youden index, whereas for prognosis its index was higher. Septicemic neonates also had significantly higher mean alpha-1-AT levels (p less than 0.05), 12-24 hours after onset of illness, as compared to healthy neonates. Alpha-1-antitrypsin could not be used as an early diagnostic aid in septicemia, but was useful for predicting outcome. Mean alpha-2-macroglobulin levels did not show significant variation in healthy and septicemic neonates. Lower mean alpha-2-MG levels were observed in neonates recovering from septicemia. As an early diagnostic aid alpha-2-MG had a low Youden index, whereas for prognosis its index was higher. CRP had a higher Youden index than alpha-2-MG for early diagnosis of neonatal septicemia and had a higher index than both alpha-1-AT and alpha-2-MG for predicting outcome in septicemia. Serial use of CRP alone is, therefore, recommended for both purposes.en_US
dc.description.affiliationDepartment of Pediatrics, Maulana Azad Medical College, New Delhi.en_US
dc.identifier.citationSuri M, Thirupuram S, Sharma VK. Diagnostic and prognostic utility of C-reactive protein, alpha-1-antitrypsin and alpha-2-macroglobulin in neonatal sepsis: a comparative account. Indian Pediatrics. 1991 Oct; 28(10): 1159-64en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/15078
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshBacteremia --blooden_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshC-Reactive Protein --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshalpha 1-Antitrypsin --analysisen_US
dc.subject.meshalpha-Macroglobulins --analysisen_US
dc.titleDiagnostic and prognostic utility of C-reactive protein, alpha-1-antitrypsin and alpha-2-macroglobulin in neonatal sepsis: a comparative account.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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