Spot protein/creatinine ratio as a marker for fetomaternal outcome in hypertensive disorder of pregnancy

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dc.contributor.authorTaneja, Ashimaen_US
dc.contributor.authorKaur, Gagandeepen_US
dc.contributor.authorKaur, Manpreeten_US
dc.contributor.authorChaudhary, Muskanen_US
dc.contributor.authorKaur, Kulviren_US
dc.date.accessioned2020-10-16T08:01:09Z
dc.date.available2020-10-16T08:01:09Z
dc.date.issued2019-12
dc.description.abstractBackground: Gestational hypertension is defined as systolic BP level of > 140 mmHg or a diastolic BP of > 90 mmHg that occur after 20 weeks of gestation. Pre-eclampsia is the hypertensive disorder of pregnancy, associated with adverse fetomaternal complications. It is assosciated with proteinuria. 24 hours urine collection is cumbersome, time consuming and potentially misleading if collected inaccurately. The spot P/C ratio has been considered equivalent to 24-hour urinary protein for predicting proteinuria. Aim of study was to compare spot P/C ratio to 24 hours urinary protein in patients of pre-eclampsia and to determine the fetomaternal outcome in the patients admitted in Dayanand Medical College and Hospital, Ludhiana.Methods: A prospective simple random study. It included 100 hypertensive pregnant women being evaluated for pre-elampsia, regardless of the alerting signs or symptoms. The main measures were the urinalysis of patients which included urinary spot P/C and 24 hours urinary protein excretion and the fetomaternal outcome in these patients. The data was statistically analyzed.Results: A good positive correlation existed between the P/C ratio and 24 hours protein excretion, with a correlation coefficient (r) of 0.912. The sensitivity and specificity of 24 hours urinary protein versus spot P/C ratio ranged between 86.29%-99.51% and 8.35%-99.95% respectively. The positive and negative likelihood ratio of 24 hours urinary protein versus spot P/C ratio was 48 (ranged between 6.89-334) and 0.04 (ranged between 0.01-0.16) respectively. The positive and negative predictive value of 24 hours urinary protein versus spot P/C ratio was 97.96% and 96.08% respectively. Our data showed that urine spot P/C ratio above 3.9/mg strongly predicts significant proteinuria of more than 4 gram/day.Conclusions: Spot urinary P/C ratio with suspected preeclampsia can be used as a rapid alternative test to 24 hours urinary protein.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Dayanand Medical College and Hospital, Ludhiana, Punjab, Indiaen_US
dc.identifier.citationTaneja Ashima, Kaur Gagandeep, Kaur Manpreet, Chaudhary Muskan, Kaur Kulvir. Spot protein/creatinine ratio as a marker for fetomaternal outcome in hypertensive disorder of pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2019 Dec; 8(12): 5014-5021en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207286
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20195362en_US
dc.subjectGestational hypertensionen_US
dc.subjectPre-eclampsiaen_US
dc.subjectProteinuriaen_US
dc.subjectSpot P/C ratioen_US
dc.subjectUrinalysisen_US
dc.subject24 hours urinary proteinen_US
dc.titleSpot protein/creatinine ratio as a marker for fetomaternal outcome in hypertensive disorder of pregnancyen_US
dc.typeJournal Articleen_US
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