Phytochemical and pharmacological evaluations of Polygonum lapathifolium stem extract for anthelmintic and antiemetic activity.

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dc.contributor.authorBulbul, Latifa
dc.contributor.authorSushanta, Somen Mojumder
dc.contributor.authorUddin, Md Jahir
dc.contributor.authorTanni, Shahnaj
dc.date.accessioned2014-07-21T12:12:55Z
dc.date.available2014-07-21T12:12:55Z
dc.date.issued2013-02
dc.description.abstractThe present study is an attempt to preliminary phytochemical investigation, anthelmintic and anti-emetic activity studies on methanolic extract of Polygonum lapathifolium stems. The phytochemical screening shows the presence of phytosterols, diterpens, amino acid & protein, alkaloid and flavonoids, those are responsible for antiviral, antibac-terial, antiallergic, antihypertensive, antiarrythmic, hepatoprotective, anti-inflammatory effects in mammals. In Anthelmintic activity test (using Pheretima posthuma model) five concentrations (20, 40, 60, 80 and 100 mg/ml in distilled water) of extracts were used which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal activity) of the worms, where the concentration of 60, 80 &100 mg/ml showed a significant anthelmintic activity. Observations were comparable with the standard drug at concentration of 10mg/ml of piperi-zine citrate. On the other hand, in anti-emetic test, emesis was induced by the oral administration of copper sulphate 50mg/kg body weight to four days age of young chicks using chick emesis model. The antiemetic activity was determined by calculating the mean decrease in number of retching in contrast with those of control disorders. The extracts (150 mg /kg orally) showed statistically significant antiemetic effect (90.45% Inhibition) compared with reference drug metoclopramide (50mg/kg intraperitoneally) which showed 82.48% Inhibition. From these observa-tions, it was concluded that stems extracts have potential anthelmintic and anti-emetic properties. The plant may further be explored for its various pharmacological activities.en_US
dc.identifier.citationBulbul Latifa, Sushanta Somen Mojumder, Uddin Md Jahir, Tanni Shahnaj. Phytochemical and pharmacological evaluations of Polygonum lapathifolium stem extract for anthelmintic and antiemetic activity. International Current Pharmaceutical Journal. 2013 Feb 2(3): 57-62.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/152953
dc.language.isoenen_US
dc.source.urihttps://www.icpjonline.com/documents/Vol2Issue3/04Abstract.htmen_US
dc.subjectPolygonum lapathifoliumen_US
dc.subjectPheretima posthumaen_US
dc.subjectpiperizine citrateen_US
dc.subjectchicken_US
dc.subjectmetoclopramideen_US
dc.subjectcopper sulphateen_US
dc.titlePhytochemical and pharmacological evaluations of Polygonum lapathifolium stem extract for anthelmintic and antiemetic activity.en_US
dc.typeArticleen_US
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