Pharmacological studies of certain amides of substituted ethylenediamines - I.

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dc.contributor.authorSethi, O Pen_US
dc.contributor.authorIsmail, A Men_US
dc.contributor.authorPillae, K Ken_US
dc.contributor.authorBhatia, O Sen_US
dc.contributor.authorTrivedi, B Men_US
dc.date.accessioned1981-01-01en_US
dc.date.accessioned2009-06-01T06:43:59Z
dc.date.available1981-01-01en_US
dc.date.available2009-06-01T06:43:59Z
dc.date.issued1981-01-01en_US
dc.description.abstractFive substituted amides of ethylenediamines produced hypotension in dogs, which was not blocked by atropine, mepyramine and propranolol. The amides potentiated the pressor responses to Adr and NA and antagonised the depressor responses to Ach and histamine. The compounds also antagonised Ach-induced contractions on the frog rectus abdominis muscle and of carbachol on rat isolated colon suggesting d-tc and atropine-like actions respectively. Antihistaminic activity was observed on guinea pig isolated ileum as on dog blood pressure. Adr and NA-induced relaxation of rabbit isolated jejunum was potentiated. Finally Adr and NA-induced contractions of rat isolated seminal vesicle was antagonised.en_US
dc.identifier.citationSethi OP, Ismail AM, Pillae KK, Bhatia OS, Trivedi BM. Pharmacological studies of certain amides of substituted ethylenediamines - I. Indian Journal of Physiology and Pharmacology. 1981 Jan-Mar; 25(1): 1-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107613
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAmides --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshChemical Phenomenaen_US
dc.subject.meshChemistryen_US
dc.subject.meshColonen_US
dc.subject.meshDogsen_US
dc.subject.meshEthylenediamines --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIleumen_US
dc.subject.meshJejunumen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction --drug effectsen_US
dc.subject.meshMuscle, Smooth --drug effectsen_US
dc.subject.meshMuscles --drug effectsen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.subject.meshSeminal Vesiclesen_US
dc.titlePharmacological studies of certain amides of substituted ethylenediamines - I.en_US
dc.typeJournal Articleen_US
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