Association of the Lipoprotein Lipase S447X and Neuropeptide Y Leu7Pro Genetic Polymorphisms with the Lipid Profiles of Individuals with and without Evidence of Coronary Artery Disease.

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dc.contributor.authorPinheiro, W. O.
dc.contributor.authorMarques, C. R.
dc.contributor.authorRios-Santos, F.
dc.contributor.authorFernandes, M. D. B.
dc.contributor.authorSantos, D. B.
dc.contributor.authorKlein, S. O. T.
dc.contributor.authorOliveira, F. S.
dc.contributor.authorGonzales, A.
dc.contributor.authorFreitas, D. C.
dc.contributor.authorPark, J. Y.
dc.contributor.authorPietro, G. Di
dc.date.accessioned2017-02-09T05:45:43Z
dc.date.available2017-02-09T05:45:43Z
dc.date.issued2016
dc.description.abstractBackground: Coronary artery disease (CAD) is a multifactorial disease whose etiogenesis involves a number of environmental, genetic and lifestyle-related factors. Genetic polymorphisms are noteworthy among these factors because they alter gene expression and, thus, the functions of the respective products. Methods: A case-control study was conducted in the Cardiology Institute, with 79 subjects classified as cases with CAD, and 96 subjects as controls without CAD or other disease. In this study, we evaluated the association between the single-nucleotide polymorphisms (SNPs) of S447X and Leu7Pro of the lipoprotein lipase (LPL) and neuropeptide Y (NPY) genes, respectively. Results: No differences were found in the frequencies of LPL SNP between the cases and controls. However, the LPL 447X allele carriers exhibited a near-significant difference in the triglycerides (p=0.086) and higher mean in the HDL-c (p=0.018). NPY polymorphisms proved to be infrequent in this study population, and no significant difference was observed between the groups. Conclusions: Our findings provide further support of the genetic polymorphisms effect on the lipid metabolism control. So, further studies are needed to assess the functional effect of this and other polymorphisms, on LPL and in the NPY activity, and their impact on CAD risk.en_US
dc.identifier.citationPinheiro W. O., Marques C. R., Rios-Santos F., Fernandes M. D. B., Santos D. B., Klein S. O. T., Oliveira F. S., Gonzales A., Freitas D. C., Park J. Y., Pietro G. Di. Association of the Lipoprotein Lipase S447X and Neuropeptide Y Leu7Pro Genetic Polymorphisms with the Lipid Profiles of Individuals with and without Evidence of Coronary Artery Disease. British Journal of Medicine and Medical Research. 2016; 16(5): 1-10.en_US
dc.identifier.issn2231-0614
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/183303
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/abstract/15028en_US
dc.subjectCoronary artery diseaseen_US
dc.subjectlipoprotein lipaseen_US
dc.subjectneuropeptide Yen_US
dc.subjectsingle-nucleotide polymorphismsen_US
dc.titleAssociation of the Lipoprotein Lipase S447X and Neuropeptide Y Leu7Pro Genetic Polymorphisms with the Lipid Profiles of Individuals with and without Evidence of Coronary Artery Disease.en_US
dc.typeArticleen_US
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