Circulating Tumor Cells – A Review

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dc.contributor.authorVerghese, Ren_US
dc.contributor.authorSrinath, Sen_US
dc.contributor.authorJayaram, Cen_US
dc.date.accessioned2023-07-14T07:04:29Z
dc.date.available2023-07-14T07:04:29Z
dc.date.issued2022-12
dc.description.abstractContext: Circulating tumor cells (CTCs) are those cells that separate from the primary tumor to enter circulation. This is facili- tated by Epithelial -Mesenchymal Transition (EMT) or through Non EMT based modalities by passive entry into circulation. CTCs are responsible for causing distant metastasis. Objectives: This review article briefly describes few of the mechanisms of CTC production and survival and few methods that are used to detect CTCs Materials and Methods: Data was collected and analyzed from published literature and electronic database searches of PubMed and Google Scholar. Result: CTCs acquire genetic alteration that differentiates them from the primary tumor. Majority of CTCs do not survive in the circulation but the few that do, do so by adapting various survival mechanisms. Conclusion: Detection of CTCs help in the early diagnosis of cancer, providing patient tailored therapy and for monitoring of cancer.en_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Government Dental College and Research Institute, Bengaluru, Indiaen_US
dc.identifier.citationVerghese R, Srinath S, Jayaram C. Circulating Tumor Cells – A Review. Oral and Maxillofacial Pathology Journal. 2022 Dec; 13(2): 141-145en_US
dc.identifier.issn2322-0384
dc.identifier.issn0976-1225
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/218482
dc.languageenen_US
dc.publisherKairali Society of Oral and Maxillofacial Pathologistsen_US
dc.relation.issuenumber2en_US
dc.relation.volume13en_US
dc.source.urihttps://ompj.org/files/ompj%2013%202%20article%20final%2016-ae730976e4acbc5879e27882159d6ddc20242491.pdfen_US
dc.subjectCirculating Tumor Cellsen_US
dc.subjectcanceren_US
dc.subjectmetastasisen_US
dc.subjectepithelial-mesenchymal transitionen_US
dc.titleCirculating Tumor Cells – A Reviewen_US
dc.typeJournal Articleen_US
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