The role of histone modifications in leukemogenesis
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Date
2020-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
Histone modifications play a critical role in coordinating accurate gene expression. Aside from geneticmutations which cause altered DNA sequence, it has become increasingly clear that aberrant post-translationalmodifications of histone tails are also associated with leukemogenesis. The functional roles of specific histonemarks has informed the basis of our understanding for underlying mechanisms of leukemia, while globalanalyses of interacting histone modifications has begun to distinguish subtypes of leukemia with prognosticand therapeutic implications. In this current era of personalized and precision medicine, it will be necessary tonot only identify the specific genetic mutations present in a patient’s leukemia but to also appreciate thedynamic chromatin states which are driven by histone modifications that can aid our diagnostic and therapeuticstrategies for improved management of leukemia.
Description
Keywords
Histone modification, leukemia, chromatin, methylation, acetylation
Citation
Birch Noah W, Shilatifard Ali. The role of histone modifications in leukemogenesis. Journal of Biosciences. 2020 Jan; : 1-5