Chalcones bearing N, O, and S-heterocycles: Recent notes on their biological significances
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Date
2019-08
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Publisher
Open Science Publishers LLP
Abstract
Because of its relatively easy synthesis, chalcone skeleton has been as a point of interest for organic and medicinalchemists from research groups worldwide. Chalcone scaffold constitutes the core of some interesting biologicallyactive natural products. Chalcone derivatives are among feasible potent active agents, such as anticancer, antibacterial,antifungal, antileishmanial, antimalarial, and antiviral. Due to the knowledge of heterocyclic chemistry, recentlychalcones bearing heterocyclic moieties have been synthesized and biologically investigated for specific target ofdiseases. The current review focuses on the latest application of chalcones integrated with N, O, and S-heterocyclicsystem and their wide spectrum of biological performance during 10 years (2010–2019). The results reported inthe review indicate that many chalcone-heterocycle hybrids may be useful as future drug candidates due to theircomparable or higher activity than that of the standards.
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Keywords
Chalcones, heterocyclic, N, O, S-heteroaromatic, biological activity, potent drugs.
Citation
Ardiansah Bayu. Chalcones bearing N, O, and S-heterocycles: Recent notes on their biological significances. Journal of Applied Pharmaceutical Science. 2019 Aug; 2019 Aug: 117-129