Frequency of Candida Infection in Post Chemotherapy Acute Leukemia Patient with Febrile Neutropenia

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Date
2020-03
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Ibn Sina Academy of Medieval Medicine & Sciences
Abstract
Objective: In this study our main goal is to evaluate thefrequency of candida infection in post chemotherapy febrileneutropenia patient with acute leukemia.Method: This prospective type of observation study carried outat Department of Haematology of Bangabandhu Sheikh MujibMedical University (BSMMU) from September 2016 to August2017. A total 63 patients of acute leukaemia (AML and ALL)were admitted in the Department of Haematology in BSMMU.Patients were selected by purposive sampling. A typedquestionnaire was supplied to all patients and those who gavethe written consent were selected as cases.Results: In the study, it was found that 19 (30.2%) patientsbelonged to age ≤20 years followed by 19 (30.2%) of 21-30years, 13 (20.6%) 31-40 years, 6 (9.5%) 41-50 years and 6(9.5%) >50 years of age. Immunophenotypically AML wasfound in 35 patients which was 55.6% of study population, BALL in 9 (14.3%), T ALL in 5 (7.9%) and APL in 2 (3.2%)patients. Majority of the patients 28 (44.4%) were found inconsolidation phase of chemotherapy followed by 26 (41.3%)in induction phase, 5 (7.9%) in relapse, 3 (4.8%) in re-inductionand 1 (1.6%) in palliative phase. 6 (9.5%) patients were foundpositive for throat swab for Candida in this study and bloodculture were negative for candida. Among the AML patients 4(66.7%) patients were found positive for candida in throat swaband 36 (64.3%) were found negative.Conclusion: In the study, it was found that among candida inthroat swab were more common in AML than ALL. Cause wasunknown but might be due to Reduce duration of neutropeniaby applying G-CSF and empirical local and systemic antifungaltherapy.
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Candida Infection, Leukemia, Lymphoma, Myelodysplastic Syndrome.
Citation
Islam Mohammad Nazmul, Islam Shafiqul, Rehnuma Saiqa, Wasim Mohammad, Khanam Aklima, Azam Md. Shafiul, Rahman Farzana, Aziz Mohammad Abdul. Frequency of Candida Infection in Post Chemotherapy Acute Leukemia Patient with Febrile Neutropenia. International Journal of Medical Research Professionals. 2020 Mar; 6(2): 69-73
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https://imsear.searo.who.int/handle/123456789/203582
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International Journal of Medical Research Professionals