Comparative Study of Clonidine Vs Dexmedetomidine for Hemodynamic Stability and Postoperative Analgesia during Laproscopic Surgery
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Date
2019-01
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International Society for Contemporary Medical Research
Abstract
Introduction: Alpha-2 (α2) adrenergic receptor agonists,clonidine and dexmedetomidine, are widely used as adjuvantsduring anesthesia for analgesic, sedative, sympatholytic, andcardiovascular stabilizing effects. The aim of this study was todifferentiate the effectiveness of intravenously administeredclonidine and dexmedetomidine for hemodynamic stabilityand postoperative analgesia during laparoscopic surgery.Materials and methods: This was a randomised, double blindand prospective study in which Group 1 included patients whoreceived 2 µg/kg of clonidine dilute in 10 ml normal saline,given slow intravenous infusion over 10 minutes beforeinduction of general anaesthesia. Group 2 patients received 1µg/kg of dexmedetomidine diluted in 10 ml of normal saline,given slowly intravenous infusion over 10 minutes beforeinduction of general anaesthesia.Results: The data was presented as Mean ± SD. Groups werecompared by independent student’s t test. Groups were alsocompared by repeated measure analysis of variance (ANOVA)using general linear models (GLM). The mean scores of SBPwere higher in group 1 among both the groups over the periods.The mean scores of DBP in both groups was similar over theperiods with slightly being higher in Group 1 especially after30 min to till end (Extubation) as compared to Group 2.Conclusion: It can be concluded that α 2 agonists were foundto be effective in attenuating the hemodynamic responseto pneumoperitoneum during laparoscopic surgeries andprovides reliable postoperative analgesia and sedation whenused as a premedication agent
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Keywords
Open Cholecystectomy and Pyelolithotomy Surgery, Postoperative Pain, Bupivacaine, Ketamine
Citation
Gautam Pooja. Comparative Study of Clonidine Vs Dexmedetomidine for Hemodynamic Stability and Postoperative Analgesia during Laproscopic Surgery . International Journal of Contemporary Medical Research . 2019 Jan; 6(1): A1-A7