Mortality & clinical characteristics of hospitalized adult patients with HIV in Pune, India.

Sobhani, Ramona; Basavaraj, Anita; Gupta, Amita; Bhave, Ashok S; Kadam, Dilip B; Sangle, Shashikala A; Prasad, Haridas B; Choi, Joline; Josephs, Joshua; Gebo, Kelly A; Morde, Shweta N; Bollinger, Robert C; Kakrani, Arjun L

Mortality & clinical characteristics of hospitalized adult patients with HIV in Pune, India.

Date

2007-08-13

Authors

Abstract

BACKGROUND & OBJECTIVE: In India, data regarding mortality and clinical characteristics of hospitalized HIV-infected patients are sparse, which may limit the effectiveness of new hospital-based HIV programmes providing antiretroviral therapy (ART). The objective of our study was to determine mortality and clinical characteristics of hospitalized HIV-infected individuals in a high HIV prevalence region of India. METHODS: A retrospective chart review was done of known HIV-infected adults admitted to the Medical Service of a large, public hospital in Pune, India, from January 2002 to November 2003. RESULTS: A total of 655 HIV-infected patients were identified; 489 (74.7%) were male and 4 (0.6%) were on ART. The most common illnesses reported were tuberculosis (55.8%), diarrhoea (4.2%), and alcoholic liver disease (3.7%) . The inpatient mortality was 172 (26.3%). The most common causes of death of the 172 people were tuberculosis (52.9%) and cryptococcal meningitis (7.6%). In multivariate analysis, factors associated with increased mortality were male sex (adjusted odds ratio (AOR) 1.92, 95% CI: 1.08-3.41), haemoglobin level < 7 g/dl (AOR 2.75, 95% CI:1.23-6.14), length of stay < 2 days (OR 5.78, 95%, CI: 1.82-18.4), and cryptococcal meningitis (OR 4.44, 95% CI:1.19-16.6). INTERPRETATION & CONCLUSION: In the era prior to widespread ART, a high inpatient mortality of 26 per cent was found among hospitalized HIV-infected individuals. Thus, while hospitalization is an important access and referral point for HIV care and treatment, earlier identification of HIV-infected persons must occur to ensure they will optimally benefit from the government's ART programme.

Citation

Sobhani R, Basavaraj A, Gupta A, Bhave AS, Kadam DB, Sangle SA, Prasad HB, Choi J, Josephs J, Gebo KA, Morde SN, Bollinger RC, Kakrani AL. Mortality & clinical characteristics of hospitalized adult patients with HIV in Pune, India. Indian Journal of Medical Research. 2007 Aug; 126(2): 116-21