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Title: Comparative Study of Evaluation of Pain on Injection of Propofol Pretreatment with two Different Doses of Butorphanol.
Authors: Mahajan, Rajesh
Jatindra, Mukta
Kassana, Sanam
Gulati, Smriti
Nazir, Robina
Mehta, Anjali
Keywords: Propofol
Issue Date: Jul-2015
Citation: Rajesh Mahajan, Mukta Jatindra, Sanam Kassana, Smriti Gulati, Robina Nazir, Anjali Mehta. Comparative Study of Evaluation of Pain on Injection of Propofol Pretreatment with two Different Doses of Butorphanol. JK Science Journal of Medical Education and Research. 2015 Jul-Sept. 17(3): 152-157.
Abstract: In a prospective, double-blind, placebo-controlled, randomized trial one-hundred-sixty eight ASA I-II adults, undergoing laparoscopic cholecystectomy were randomly assigned into 3 groups of 56 each. Group L received lidocaine 2% (40 mg), Group B-1 received butorphanol 1 mg. and Group B-2 received butorphanol 2 mg. One min after pretreatment patients received one-fourth of the total calculated dose of propofol (2.5 mg/kg) over 5 s. In the lignocaine group 28 (50.00%) patients had pain during propofol injection as compared with 11 (19.64%) and 9 (16.07%) in the butorphanol 1mg and butorphanol 2mg groups, respectively (P < 0.05). Intergroup comparison revealed that although the incidence of pain at propofol injection was more in lignocaine group, the severity was primarily mild and comparable among the three groups (P > 0.05). Butorphanol decreased the frequency (P < 0.05) of propofol pain when compared with lidocaine. However severity of pain on injection of propofol was comparable among both the groups given pretreatment with butorphanol. (P > 0.05). No difference in complications, such as pain, edema, wheal, or flare response, were observed at the injection site within the first 24 h after the operation. Duration of analgesia was higher in Group-B-2 compared to other two groups. (142.5±33.96 minutes in Group-B-2, 76.07±23.56 minutes in Group-B-1 and 80.35±21.48 minutes in Group -L). However this was also associated with higher number of patients in deep sedation at 30 minutes. Pretreatment with butorphanol 1 mg or 2mg are equally effective in relieving pain on injection of propofol & more effective than lignocaine.
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