The evaluation of the amount and sustain release of antifungal agent clotrimazole incorporated in different polymer matrix in artificial saliva at a pH of 6.2.
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Date
2015-10
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Abstract
Background: Candidiasis in the oral cavity is an opportunistic infections, the most common species involved is Candida
albicans. Clotrimazole (CTZ) is the first line broad-spectrum antifungal drug that has been widely used for the prophylaxis
and treatment of oral and vaginal candidiasis. It is seen that the effect of drug is better locally as compared to oral intake.
The aim of the present study is to find out the quantum release of clotrimazole from the incorporated materials in the artificial
salivary medium at the pH of 6.2 and to access the physical properties of the clotrimazole incorporated reliner and tissue
conditioner. Methods: The antifungal clotrimazole is incorporated in two types of denture base material used for this study
at 2%, 5% and 10% concentration by weight. The release of clotrimazole out of polymer matrix was studied at various pH.
The main property of tensile strength of the specimen before and after the chemical release of the clotrimazole was tested.
Result: Concentration was maximum on 8th day and uniformly decreased thereafter. The maximum amount of release upto
8th day was 2.52, 4.23, 9.84 mg for 2%, 5% and 10% respectively. Conclusion: Topical release of antifungal agents is
more effective than systemic intake, which has adverse effect like renal toxicity and CNS toxicity.
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Keywords
Clotrimazole, candida albicans, kinetics, soft liners, tissue conditioner
Citation
Sabarigirinathan C, Vinayagavel K, Rupkumar P, Prabhu G Sriram, Jeyanthikumari T, Rajakumar M, Chubey Anshul, Meena N Sangeetha, Elavarasan S. The evaluation of the amount and sustain release of antifungal agent clotrimazole incorporated in different polymer matrix in artificial saliva at a pH of 6.2. Annals of International Medical and Dental Research. 2015 Oct-Dec; 1(3): 195-198.