Drug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen.
Date
2010-02
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Abstract
Multidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing
countries. The prevalence of drug resistance in Mycobacterium tuberculosis (MTB) isolates (n=692) from
Mpumalanga province was assessed. In total, 692 (64%) MTB strains from cases with pulmonary TB were
tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960
instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs. Resistance to one
drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. The prevalence of MDR-TB ranged from
6.7% for three drugs to 34% for four drugs, with significant predictors being patients’ age-groups of 25-54
years (p=0.0012) and >55 years (p=0.007). The result showed a high level (58.4%) of MDR-TB from cases
in Mpumalanga province. To achieve a higher cure rate in this province, drug-susceptibility tests must be
done for every case.
Description
Keywords
Drug resistance, Microbial, Mycobacterium tuberculosis, Risk factors, Tuberculosis, South Africa
Citation
Green E, Obi C.L, Nchabeleng M, Villiers B.E. de, Sein P.P, Letsoalo T, Hoosen A.A, Bessong P.O, Ndip R.N. Drug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen. Journal of Health, Population and Nutrition. 2010 Feb; 28(1):7-13.