Diabetic Retinopathy and Homocysteine in Newly Diagnosed Type 2 Diabetes Mellitus.
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Date
2013-07
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Abstract
Background: Diabetic retinopathy is the commonest complication that occurs from the very beginning in patients
with diabetes mellitus (DM). DM itself leads to increased homocysteine (Hcy) level. It is postulated that
hyperhomocysteinaemia causes retinal vascular damage as Hcy is an established vasculotoxic agent and
auto-oxidation of Hcy leads to oxidative stress, endothelial dysfunction, platelet activation and thrombus
formation. Objective: The aim of the study was to evaluate the serum Hcy in newly diagnosed type 2 diabetic
subjects with diabetic retinopathy. Materials and method: A case control study was carried out in the department
of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, during the period of January 2006 to
December 2007. Total 85 newly diagnosed type 2 diabetic subjects were included in this study, 40 were case
having retinopathy and 45 were age and sex matched control without retinopathy. Serum Hcy was measured and
compared between case and control. Results: Serum Hcy level in cases was significantly higher (p<0.05)
compared to that of control (15.11±5.49 μmol/L vs. 12.59±4.01 μmol/L). Odds ratio was also determined for
hyperhomocysteinemia (OR=2.23; CI 0.9-5.45). Conclusion: Hyperhomocysteinaemia is associated with diabetic
retinopathy in newly diagnosed type 2 diabetes.
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Keywords
Homocysteine (Hcy), hyperhomocysteinaemia, diabetic retinopathy
Citation
Rahman Md Rezwanur, Arslan M Iqbal, Hoque Md Mozammel, Rahman Md Waliur, Shermin Shahana. Diabetic Retinopathy and Homocysteine in Newly Diagnosed Type 2 Diabetes Mellitus. Delta Medical College Journal. 2013 July; 1(2): 37-41.