A Prospective, Randomized, Placebo-Controlled, Trial Comparing the Effectiveness of Gabapentin, Ondansetron & Dexamethasone in Prevention of Nausea &Vomiting after Laparoscopic Cholecystectomy.
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Date
2013-07
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Abstract
Gabapentin is an anticonvulsant drug that has been shown useful in postoperative nausea and vomiting
(PONV). AIM: We compared the effects of gabapentin on PONV with ondansetron, dexamethasone and
placebo in patients undergoing laparoscopic cholecystectomy under general anesthesia. One-hundredtwenty
patients undergoing elective laparoscopic cholecystectomy were randomly assigned to one of the
following four groups: gabapentin group (G) received 600mg oral gabapentin capsule two hours before
surgery +IV 2ml saline 10-15 minutes before surgery; ondansetron group (O) received an oral placebo
two hours before surgery +IV 4mg ondansetron 10-15 minutes before surgery; dexamethasone group (D)
received oral placebo two hours before surgery +IV 8mg dexamethasone 10-15 minutes before surgery
and placebo group (P) received oral placebo two hours before surgery +IV 2ml saline 10-15 minutes
before surgery. Granisetron IV 1mg was used as rescue medication for emesis. Nausea and vomiting
were assessed by direct questioning of the patients at 1, 2, 6, 12 and 24 hours after surgery. RESULTS:
We found that the incidence of PONV (by simple yes or no) in first 24 hours was significantly lower in
gabapentin (40%) dexamethasone (30%) and ondansetron group (36.7%) as compared to placebo group
(66.7%) (P<0.05). The number of patients requiring rescue antiemetics was significantly decreased in
gabapentin (30%), dexamethasone (26.7%) and ondansetron (26.7%) group versus placebo group (60%)
(P<0.05). Gabapentin is as effective as ondansetron and dexamethasone as an antiemetic in laparoscopic
cholecystectomy patients.
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Keywords
Gabapentin, Antiemetic, Postoperative nausea, Vomiting
Citation
Semira, Abbas Zaffar, Tandon Vishal R, Bashir Amina, Kour Kirpal. A Prospective, Randomized, Placebo-Controlled, Trial Comparing the Effectiveness of Gabapentin, Ondansetron & Dexamethasone in Prevention of Nausea &Vomiting after Laparoscopic Cholecystectomy. JK Science Journal of Medical Education and Research. 2013 Jul-Sept; 15(3): 117-121.