Efficacy and Tolerability of Tamsulosin Alone and in Combination with Dutasteride in Patients of Benign Prostatic Hyperplasia.

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Date
2012-07
Authors
Arora, Sapna
Khajuria, Vijay
Kohli, Kamlesh
Gupta, Sunil
Tandon, Vishal R
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Abstract
The present prospective randomized study was conducted to find out efficacy and tolerability of tamsulosin alone (0.4mg) and tamsulosin (0.4mg) in combination with dutasteride (0.5mg) in patients of BHP. Two groups of 20 patients each received either of the regimes for 24 weeks. Both groups were evaluated for uroflowmetric, ultrasonography and AUASS parameters. Both regimes caused significant increase in Qmax, Qave, voided volume and concomitant decrease in voiding time, flow time and time to peak flow(P<0.0001). Ultrasonographically assessed prostate volume and residual urine volume decreased significantly with combination group, whereas only residual urine volume was decreased in tamsulosin group. Both groups caused improved AUASS (P<0.0001).Combination group produced more improvement than tamsulosin alone on Qmax, Qave and flow time (P<0.05) and decrease in prostate volume (P<0.001). Both regimes were well tolerated.The combination appears to have an additive effect.
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Keywords
BHP, AUA symptom score, Tamsulosin, Dutasteride
Citation
Arira Sapna, Khajuria Vijay, Kohli Kamlesh, Gupta Sunil, Tandon Vishal R. Efficacy and Tolerability of Tamsulosin Alone and in Combination with Dutasteride in Patients of Benign Prostatic Hyperplasia.JK Science Journal of Medical Education and Research. 2012 Jul-Sept;14(3): 134-138