Comparison of Esmolol and Lignocaine for Atttenuation of Cardiovascular Stress response to Laryngoscopy and Endotracheal Intubation.
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Date
2009-04
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Abstract
Direct laryngoscopy and endotracheal intubation frequently induces a cardiovascular stress response due
to reflex symbathetic stimulation. This response may be hazardous in patients with Hypertension, Coronary
artery disease, Myocardial disease, cerebrovascular disease. Numerous agents have therefore been utilized
to blunt this response. The present study was undertaken in view of above mentioned facts, to compare
effectiveness of intravenous esmolol and lignocaine in suppressing the cardiovascular stress response.
Patients were divided in to three groups of 20 patients each. Group-C did not receive any drug under
study. Group-L received lignocaine and Group-E received esmolol three minutes before intubation. All the
groups were observed for changes in haemodynamic parameters i.e. heart rate (HR) systolic and diastolic
blood pressure every minute after intubation till 5 minutes post intubation. It was found that patients given
esmolol had better attenuation of stress response to laryngoscopy and intubation than patients given
lignocaine.
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Keywords
Endotracheal Intubation, Cadiovascular stress response, Lignocaine, Esmolol
Citation
Gupta Ajay, Wakhloo Renu, Gupta Vishal, Mehta Anjali, Kapoor B B. Comparison of Esmolol and Lignocaine for Atttenuation of Cardiovascular Stress response to Laryngoscopy and Endotracheal Intubation. JK Science Journal of Medical Education and Research. 2009 Apr-June;11(2): 78-81