Safety and Efficacy of Duloxetine Versus Venlafaxine in Major Depression in Indian Patients
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Date
2006-10
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Abstract
The objective of the study was to compare the efficacy and safety of duloxetine and venlafaxine in major
depressive disorder. The study was conducted in 26 patients suffering from major depressive disorder as
per DSM-IV criteria. Patients were randomized to two groups and were given duloxetine (20,40,60mg
BD) and venlafaxine (75,150,225mg OD) for 6 weeks. The primary efficacy parameter was the Hamilton
Depression Rating Scale (HDRS-17). Secondary efficacy parameters included the Montgomery and Asberg
depression rating scale (MADRS) and clinical global impression (CGI) scale. Safety evaluation was based
on treatment emergent adverse effects and laboratory investigations. There was significant decrease in
HDRS, MADRS, CGI scores from baseline to endpoint (p<0.05) in both the groups. However the difference
in scores between two groups was not statistically significant. Total mean HDRS score decreased from
27(SD=2.5) to 4 (SD=1.2) in duloxetine group and from 29(SD=2.3) to 4 (SD=1.0) in venlafaxine group at
the end of therapy. Response and remission rate was 96% and 69% in duloxetine group as compared to
92% and 62% in venlafaxine group respectively. There was no significant difference in adverse effects
and laboratory investigation in two groups. The findings of this study indicate that duloxetine may be an
effective and safe antidepressant in Indian patients of major depressive disorder. It is equally effective to
venlafaxine in patients of depression.
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Keywords
Duloxetine, Venlafaxine, Depression
Citation
Badyal Dinesh k, Khosla Prem P, Deswal Rajinder S, Materja Prithpal S. Safety and Efficacy of Duloxetine Versus Venlafaxine in Major Depression in Indian Patients. JK Science Journal of Medical Education and Research. 2006 Oct-Dec;8(4): 195-199