Plasma Exchanges and Immunosuppression for Anti-complement Factor H Associated Hemolytic Uremic Syndrome.

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Date
2014-10
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Abstract
Background: Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure. Case Characteristics: 7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies. Intervention: Prompt initiation of plasma exchanges and immunosuppression. Outcome: Remission of hematological and kidney functions. Message: Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.
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Keywords
Corticosteroids, Hemolysis, Renal failure
Citation
Khandelwal Priyanka, Sinha Aditi, Hari Pankaj, Bagga Arvind. Plasma Exchanges and Immunosuppression for Anti-complement Factor H Associated Hemolytic Uremic Syndrome. Indian Pediatrics. 2014 Oct; 51(10): 833-835.