Plasma Exchanges and Immunosuppression for Anti-complement Factor H Associated Hemolytic Uremic Syndrome.
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Date
2014-10
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Abstract
Background: Atypical hemolytic uremic syndrome associated with autoantibodies to
complement factor H is an important cause of acute kidney injury; most patients require
dialysis and are at risk of progressive renal failure. Case Characteristics: 7 patients with
gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated
levels of anti-complement factor H antibodies. Intervention: Prompt initiation of plasma
exchanges and immunosuppression. Outcome: Remission of hematological and kidney
functions. Message: Prompt and specific management of antibody associated hemolytic
uremic syndrome is associated with favorable outcome.
Description
Keywords
Corticosteroids, Hemolysis, Renal failure
Citation
Khandelwal Priyanka, Sinha Aditi, Hari Pankaj, Bagga Arvind. Plasma Exchanges and Immunosuppression for Anti-complement Factor H Associated Hemolytic Uremic Syndrome. Indian Pediatrics. 2014 Oct; 51(10): 833-835.