Cord Blood Thyroid Stimulating Hormone Level – Interpretation in Light of Perinatal Factors.
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Date
2014-01
Journal Title
Journal ISSN
Volume Title
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Abstract
Objectives: To study the influence of perinatal factors on cord
blood TSH (CB TSH) levels.
Design: Cross-sectional study.
Setting: Tertiary care private hospital.
Methods: CB TSH levels were measured in 952 live-born infants
using electrochemiluminescence immunoassay. The effect of
perinatal factors on the CB TSH levels was analyzed statistically.
Results: The median CB-TSH was 8.75 microIU/mL (IQR = 6.475
– 12.82) with 11.5% neonates having values more than 20. CB
TSH was significantly raised in first order neonates (P <0.01) and
in babies delivered by assisted vaginal delivery and normal
delivery (P <0.01). Neonates who had fetal distress or nonprogress
of labour had significantly higher CB TSH than those
who were delivered by elective caesarean section.
Requirement of resuscitation beyond the initial steps and low
Apgar scores at 1 minute also resulted in significantly raised CB
TSH (both P <0.01). Maternal hypothyroidism, maternal
hypertension and neonates’ weight appropriateness for
gestation, gestational age and birth weight did not have
significant effect.
Conclusions: The incidence of high cord blood TSH (>20
microU/mL) is 11.45%. On multivariate analysis, requirement of
resuscitation, mode of delivery and fetal distress as indication for
LSCS were significant factors affecting CB TSH values. Hence,
these values need to be interpreted in light of perinatal factors.
Description
Keywords
Cord blood, Perinatal factors, Newborn screening, Thyroid stimulating hormone
Citation
Gupta Amit, Srivastava Smita, Bhatnagar Anjoo. Cord Blood Thyroid Stimulating Hormone Level – Interpretation in Light of Perinatal Factors. Indian Pediatrics. 2014 January; 51(1): 32-36.