Neuroprotective effect of renin angiotensin system blockers on experimentally induced Alzheimer’s disease in rats.
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Date
2015-09
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Abstract
Background: Alzheimer’s disease (AD) is a major world-wide health problem.
Much evidence points to a link between hypertension and AD. However, the exact
effects of different antihypertensive drugs on AD need to be more assessed. The aim
was to evaluate and compare the possible effects of perindopril, and candesartan on
cognitive impairment, oxidative stress markers, and brain concentrations of amyloid
beta-peptide (Aβ-P) in a rat model of induced dementia.
Methods: Thirty-two adult male Wistar rats were distributed among 4 groups;
(1) normal controls; (2) rats with dementia induced by intracerebroventricular
administration of streptozotocin (ICV-STZ) and received no treatment; (3) ICV-STZ
rats treated orally with perindopril for 3 weeks; and (4) ICV-STZ rats treated orally
with candesartan for 3 weeks. The assessed parameters were spatial memory by
Morris Water Maze test, brain tissue level of total antioxidant capacity (TAC), reduced
glutathione (GSH), lipid peroxidation product (malondialdehyde [MDA]), and Aβ-P.
Results: Both perindopril and candesartan attenuated STZ-induced memory
impairment, caused a significant increase in TAC and GSH levels, reduced MDA
levels, whereas only candesartan significantly reduced Aβ-P levels.
Conclusions: This study reports that candesartan and perindopril can reverse the free
radical induced damages and resultant memory defects, and may suggest candesartan
as worthy drugs for prevention of Aβ-P deposition in this animal model of AD.
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Keywords
Streptozotocin, Amyloid beta-peptide, Hypertension, Perindopril, Candesartan, Oxidative stress
Citation
Hewedy Wafaa A, El-Hadidy Wessam F. Neuroprotective effect of renin angiotensin system blockers on experimentally induced Alzheimer’s disease in rats. International Journal of Basic & Clinical Pharmacology. 2015 Sep-Oct; 4(5): 853-859.