Luteal function during the periimplantation period and requirement for estrogen for implantation and pregnancy maintenance in the nonhuman primate.
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Date
1984-07
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Abstract
An attempt has been made in this paper to review our present understanding of
luteal function during the periimplantation period and in particular hormonal requirement for
implantation and maintenance of early pregnancy in the non-human primate.
In a fertile cycle the corpus luteum is apparently rescued from luteolysis by chorionic
gonadotropin secreted by the implanted blastocyst, In the bonnet monkey the serum
progesterone titers during the luteal phase of a fertile cycle seems higher compared to that of
nonmated cycling monkeys. This suggested that the corpus luteum is receiving some
stimulatory signal from the blastocyst even prior to implantation. The recent demonstration
that human blastocyst in culture secretes into the medium human chorionic gonadotropin
essentially support the above assumption. However, attempts to extend the luteal phase of
cycling unmated monkeys with exogenous human chorionic gonadotropin injection has
hitherto not met with complete success suggesting that there could be other than chorionic
gonadotropin, additional luteal stimulatory factors the unimplanted blastocyst is secreting.
Corpus luteum is the principle source of both progesterone and estrogen produced during
the periimplantation period and dysruption of luteal function, brought about by either
lutectomy or ovariectomy or luteinizing hormone antiserum treatment, followed by progesterone
supplementation leads to maintenance of pregnancy. This has lead to questioning
the need for estrogen in the maintenance of early pregnancy. Recent work using
Zuclomiphene, an antiestrogen during days 5–11 of cycle in rhesus monkeys mated between
day 9–14, has however, suggested that estrogen may be required for implantation. Further
work is needed to arrive at an unequivocal decision regarding the need for estrogen in
maintenance of early pregnancy in the primate.
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Keywords
Estrogen, implantation, corpus luteum, non-human primate
Citation
Moudgal N R. Luteal function during the periimplantation period and requirement for estrogen for implantation and pregnancy maintenance in the nonhuman primate. Journal of Biosciences. 1984 July; 6(suppl_2): s93-s96.