Hepatoprotective activity of Parmelia perlata (Huds.) Ach. against CCl4 induced liver toxicity in Albino Wistar rats.
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Date
2014-02
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Abstract
Many plants have been claimed to possess liver protecting activity. But, due to scarcity of potent modern
medicine to treat severe liver diseases, many folk remedies of plant origin have been scientifically evaluated for
their potential hepatoprotective activity in experimental animal models. Parmelia perlata (Huds.) Ach. (lichen,
Parmeliaceae), commonly known as Dagad phool or stone flower in India, is mentioned in Indian Materia
Medica as useful in treating a number of ailments. In the present study, hepatoprotective activity of aqueous
slurry of P. perlata was investigated in CCl4 intoxicated Albino Wistar rats and the results were compared with,
Silymarin. Intraperitoneal injection of CCl4, produced a marked elevation in the level of biochemical markers
such as Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase
(SGPT), bilirubin, cholesterol and triglycerides. Oral administration of P. perlata aqueous slurry at 0.7 g / kg and
1.0 g / kg in CCl4 intoxicated rats showed marked decrease in the level of biochemical markers and results were
at par with the effect shown by Silymarin. The results of histopathological analysis were in compliance with the
findings of blood biochemical parameter analysis. This study confirms that P. perlata aqueous slurry has phytocomponents
with hepatoprotective potential.
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Keywords
Lichen, Parmelia perlata, Hepatoprotection, Carbon tetrachloride
Citation
Shailajan Sunita, Joshi Mayuresh, Tiwari Bhavesh. Hepatoprotective activity of Parmelia perlata (Huds.) Ach. against CCl4 induced liver toxicity in Albino Wistar rats. Journal of Applied Pharmaceutical Science. 2014 Feb; 4(2): 70-74.