Enhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with ß-cyclodextrine.
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Date
2011-11
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Abstract
Motion sickness is a very common disturbance of the inner ear that is caused by
repeated motion such as from the swell of the sea, the movement of a car, the motion of a plane in
turbulent air, etc. Most medications for motion sickness need to be taken at least 30 minutes prior
exposure to the activity that can cause the problem. This project is based on the hypothesis that
Mouth Dissolving Films (MDF) are rapidly dissolving dosage forms which when placed in the
mouth release the drug immediately. These dosage forms would be preferred by pediatric and
geriatric patients since these are not associated with fear of choking. The fast dissolving films
prepared by solvent casting method with suitable appearance, mechanical strength, peelability and
disintegration time were obtained using Methocel E-5 as a primary film former. Meclizine HCl, a
poorly water soluble and bitter drug could be successfully incorporated in the fast dissolving films
with the help of solubilizers such as β-Cyclodextrine and PEG-400.
Description
Keywords
Meclizine HCl, Methocel E-5, β-Cyclodextrine, PEG-400, Solvent Casting Method, Motion Sickness, Mouth Dissolving Film (MDF)
Citation
Gupta M M, Patel Mitul G, Kedawat Madhulika. Enhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with ß-cyclodextrine. Journal of Applied Pharmaceutical Science. 2011 Nov; 1(9): 150-153.