Interpenetrating polymer network of cross-linked blend microspheres for controlled release of Acebutolol HCl.
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Date
2011-08
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Abstract
Carbohydrate polymeric blend microspheres consisting of chitosan (CS) and poly (vinyl
alcohol) (PVA) were prepared by water-in-oil (W/O) emulsion method. These microspheres were
crosslinked with glutaraldehyde and loaded with Acebutolol HCl, an anti hypertensive drug. The
microspheres were characterized by Fourier transform infrared spectroscopy (FTIR), Differential
scanning calorimetry (DSC), X-Ray diffraction (X-RD) and Scanning electron microscopy
(SEM).The FTIR spectroscopy explains the crosslinking between the CS-PVA. DSC& X-RD
indicated the molecular level distribution of Acebutolol HCl drug in the polymer matrix. The
SEM of the microspheres suggested the formation of spherical particles. Swelling experiments on
the microspheres provided important information on drug diffusion properties. Release data have
been analyzed using an empirical equation to understand the nature of transport of drug
containing solution through the polymeric matrices. The controlled release characteristic of the
matrices for Acebutolol HCl was investigated in pH 7.4 media. The results indicate that the drug
was released in a controlled manner up to 10 h.
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Keywords
Chitosan (CS), Poly (Vinyl alcohol) (PVA), microspheres, Acebutolol HCl, drug delivery, blend, crosslinking
Citation
Ramakrishna P, Mallikarjuna B, Babu A Chandra, Sudhakar P, Rao K Chowdoji, Subha M C S. Interpenetrating polymer network of cross-linked blend microspheres for controlled release of Acebutolol HCl. Journal of Applied Pharmaceutical Science. 2011 Aug; 1(6): 212-219.