Amikacin: Area under curve for once daily dose and its correlation with plasma concentration at six hours post infusion.
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Date
2003-03
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Abstract
Aminoglycosides are commonly used for gram-negative septicemia. Formerly, peak and trough plasma levels were the monitoring parameters for conventional dose which was every eight hours. At present the recommended dose is once daily and the recommended monitoring parameters are the area under concentration time curve and the six-hour (range 146-180) for the area under curve and 6.79 milligrams per liter (range 5.6-7.9) for the six-hour plasma concentration post-infusion. The correlation of the area under curve and the six-hour plasma concentration post-infusion was reported in a linear equation with significance.
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Keywords
Aminoglycosides, Amikacin, Area under curve
Citation
Kolladarungkri Teera, Udol Kamol, Sangsiriwut Kantima, Pisalsarakij Dujpratana, Suwanagool Surapol. Amikacin: Area under curve for once daily dose and its correlation with plasma concentration at six hours post infusion. Siriraj Medical Journal, 2003 Mar; 55(3): 133-138.