Hypolipidemic activity of Hibiscus rosa sinensis root in rats.
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Date
2009-12
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Abstract
The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver homogenate and reactivation of plasma PHLA and hepatic total lipoprotein lipase activity. The hypolipidemic activity of Hibiscus rosa sinensis root was compared with a standard drug guggulipid (200 mg/kg body wt/day p.o.), a known lipid- lowering agent in both models. Histopathological findings in rat liver supported the protective role of H. rosa sinensis root extract in preventing cholesterol-rich HFD-induced hepatic steatosis.
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Keywords
Hibiscus rosa sinensis, Triton, Cholesterol hyperlipidemia, Hypolipidemic agent, Post-heparin lipolytic activity, Hepatic lipoprotein lipase activity, Hepatic steatosis
Citation
Kumar Vishnu, Singh Pradyumn, Chander Ramesh, Mahdi Farzana, Singh Sushma, Singh Ranjana, Khanna Ashok Kumar, Saxena Jitendra Kumar, Mahdi Abbas Ali, Singh Vinod Kumar, Singh Raj Kumar. Hypolipidemic activity of Hibiscus rosa sinensis root in rats. Indian Journal of Biochemistry & Biophysics. 2009 Dec; 46(6): 507-510.