European Journal of Medicinal Plants

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https://imsear.searo.who.int/handle/123456789/151205

Chief Editors: Dr. Marcello Iriti, Dr. Valentina Savo
ISSN: 2231-0894

Frequency: Quarterly

Language: English

Open Access Peer-reviewed journal

Web site: https://www.sciencedomain.org/journal-home.php?id=13

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Browsing European Journal of Medicinal Plants by Subject "Acalypha wilkesiana"

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    Antibacterial and Antifungal Activity of Acalypha wilkesiana.
    (2013-01) Haruna, Muyideen T; Anokwuru, Chinedu P; Akeredolu, Abosede A; Akinsemolu, Adenike A; Alabiv, Okunola A
    The antimicrobial activity of the leave of Acalypha wilkesiana methanolic extract and its four derivative fractions were determined on human pathogenic bacteria namely strains of Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus vulgaris and Escherichia coli and fungi; Aspergillus niger, A. flavus, A. carbonerium, Trichophyton mentagrophytes and Candida albicans. Methanolic extract (200 mg/ml) and its fractions were tested on the bacteria and fungi using the disc diffusion method. In vitro antibacterial and antifungal activity were screened by using Mueller Hinton Agar (MHA) and Potato Dextrose Agar (PDA) respectively. The minimum inhibitory concentration for the bacteria and fungi were also determined. Results showed broad spectrum antimicrobial activity against the Gram-negative and Gram-positive bacteria but same cannot be said about its activity against the fungi. The ethyl acetate fraction inhibited the growth of more bacteria and fungi compared to the other fractions; however, the aqueous extract was more effective on the bacteria isolates as it showed the lowest MIC for more bacteria compared to the other fractions. The extract and its fractions were active against bacteria which some standard antibiotics were not able to inhibit. Methanolic extract of A. wilkesiana leaves and its fractions showed a better antibacterial activity than antifungal activity. The fact that the plant was active against both clinical and laboratory isolates is an indication that it can be a source of very potent antibiotic substances that can be used against drug resistant microorganisms. The search for new drugs to counter the challenges posed by resistant strains of bacteria and some fungi might have started yielding results as the investigation of this plant has demonstrated enormous therapeutic potential.
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    Hyponatremic Effect of Aqueou Leaf Extract of Acalypha wilkesiana in Male Wistar Rats.
    (2012-10) Iniaghe, O M; Oyewo, E B; Egharevba, O
    Aims: To evaluate the hyponatremic effect of aqueous leaf extract of Acalypha wilkesiana in male wistar rats. Study Design: In vivo study. Place and Duration of Study: Department of Biochemistry, Faculty of Natural Sciences, Ambrose Alli University, Ekpoma Nigeria, between August 2011 and October 2011. Methodology: Thirty two male wistar rats of average body weights (167.50 ± 5.56 g) were grouped into four (A-D), of eight rats each. Group A received distilled water (control), while constituted doses of 2500, 5000 and 10000 mg/kg body weight of the extract were administered once daily for 14 days to animals in group B, C and D respectively. The effect of administration of this extract on serum sodium ions and weight parameters was evaluated. Serum activities of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase; serum proteins, bilirubin, creatinine, urea, uric acid, potassium, calcium and phosphate ion concentrations were determined. Results: Significant reductions (p<0.05) were observed in serum sodium ion at doses above 2500 mg/kg body weight and this reduction was significantly dose-dependent up to 10000 mg/kg body weight of the extract. No significant differences (p>0.05) were obtained in all other serum and weight parameters determined. Conclusion: This extract at the administered doses is safe, and its hyponatremic action suggests that it could be used as a diuretic.