Browsing by Author "YADAV, R."

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    A PROSPECTIVE OPEN-LABEL STUDY TO COMPARE THE EFFICACY AND SAFETY OF TOPIRAMATE ALONE VERSUS TOPIRAMATE WITH VITAMIN D IN PROPHYLACTIC TREATMENT OF PATIENTS WITH MIGRAINE
    (Innovare Academic Sciences Pvt. Ltd., 2025-03) DIXIT, A.; BRAHEMI, M.; KHAN, N. F.; YADAV, R.; SINGH, C. V
    and sound sensitivity. While acute treatments are common, preventive therapies are underutilized. Recent studies suggest combining vitamin D with Topiramate, an anticonvulsant, could enhance prevention, reducing both attack frequency and duration. Therefore, the present study compares the safety and efficacy of Topiramate alone versus topiramate with Vitamin D. Methods: A study was conducted on 100 migraine patients to compare the effect of topiramate alone versus topiramate with vitamin D. Pain severity and disability were measured using a Visual Analog Scale (VAS), Migraine Disability Assessment Score (MIDAS), and Migraine Severity (MIGSEV) scores over 12 w, excluding patients with other medical conditions. Results: Both the Topiramate and Topiramate with Vitamin D groups showed significant reduction in VAS, MIDAS, and MIGSEV scores after 12 weeks. Migraine without aura was more common in both groups. The Topiramate with Vitamin D group also experienced increased serum calcium and Vitamin D levels. Both groups showed significant improvements in pain and disability, with the Topiramate with Vitamin D group showing better results. Conclusion: Combining topiramate with vitamin D effectively reduces migraine frequency and disability.