Browsing by Author "Sultana, N"
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Item Association of Hypertension and Smoking with Ischaemic Stroke.(2010) Kirtania, K; Sultana, N; Ahmed, S; Khatun, AHypertension is one of the most important modifiable risk factors for ischemic stroke. Cigarette smoking is a risk factor for atherosclerotic disease. There is a strong relationship between hypertension and cigarette smoking with ischaemic stroke. A case control study was undertaken to see the association of hypertension and cigarette smoking with ischaemic stroke. The study was done from January to December 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. A total of 60 subjects were selected as study population. Among them 30 were diagnosed case of ischaemic stroke and 30 were age-and sex-matched control subjects. It was found that 60% patients of case group and 20% respondents of control group were hypertensive and diffrence was significant. Study showed that 56.66% of cases and 53.33% of controls were smoker and the findings were insignificant. The mean duration of smoking was 27.41 ± 2.98 years in cases and 15.63 ± 2.85 years in controls which was significant. The study suggests that hypertension is significantly associated with ischaemic stroke and longer duration of smoking also associated with ischaemic stroke.Item Association of Serum Calcium and 24 Hours Urinary Excretion of Calcium in Patients of Preeclampsia.(2010) Khatun; Kirtania, K; Shima, T S; Ferdous, S; Shahnaz, A; Yeasmin, F; Sultana, NPreeclampsia is a leading cause of fetal growth retardation, infant morbidity, mortality and maternal death. Several biochemical changes occur during the course of the disease, among them serum total calcium and 24 hr urinary calcium excretion rate have drawn remarkable attention. A case control study was designed to see the association of serum calcium and 24 hours urinary excretion of calcium in patients of pre- eclampsia. The study was done from July 2008 to June 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. Total 60 subjects were selected as study population. Among them 30 were diagnosed case of preeclampsia and 30 were age- and sex-matched normal pregnant female healthy control. It was found that the mean measured serum calcium level in case group were 1.96 ±0.17 ( mean±SD ) mmol / l and that of control group were 2.34±0.12 (mean±SD) m mol/ l respectively. The mean 24 hr urinary calcium excretion level were 94.40 ±10.68mg/24 hr (mean±SD) in case group and that of control group were 154.35±66.68 (mean ±SD) mg / 24 hr respectively. The study suggests that low level of serum calcium and urinary excretion of calcium was associated with Pre-eclampsia.Item Blood pressure response to 12 weeks of isometric handgrip exercise training in prehypertensive adult males(?Eldaghayes Publisher, 2024-10) Sultana, N; Rama Devi, M; Ambareesha, K.Background: Studies have shown that isometric handgrip (IHG) exercise is effective in reducing the systolic blood pressure (SBP) in hypertensive individuals. The aim of this study is to determine the effectiveness of IHG exercise along with salt restriction in pre-hypertensive individuals to bring them to normotensive levels. Dynamic exercise is physically demanding, lacks objective quantification, and is cumbersome. Aims and Objectives: (1) To study the effect of IHG exercise on SBP, diastolic blood pressure (DBP), and mean arterial blood pressure (MABP) in the exercise group; (2) To determine the SBP, DBP, and MABP pre- and poststudy in the control group; and (3) To compare the blood pressure difference pre- and postexercise among the exercise and control groups. Materials and Methods: 60 prehypertensive males were selected; SBP, DBP, and MABP were recorded as 0 weeks. 30 of them were subjected to only salt restriction, referred to as the control group; another 30 were subjected to salt restriction along with 30% maximal voluntary contraction (MVC) IHG exercise, 5 sessions per day with each hand performing every alternate day for 12 weeks. SBP, DBP, and MABP were recorded every 3rd week. The difference of 0-week and 12-week variable values was compared between the control and training groups. Results: A significant reduction by a mean value of 5.2 ± 2.15 was seen in SBP among the training group, whereas the difference in other variables was not significant. Conclusion: IHG exercise at 30% MVC, in combination with lifestyle modification, can be recommended to patients with prehypertension and can be a part of a comprehensive treatment regimen.Item Central Obesity Plays an Important Role for the Development of Type 2 Diabetes in Bangladeshi Women.(2014-07) Faruque, M O; Sultana, N; Mannan, A; Ali, LBackground: Diabetes mellitus coexists at a greater frequency with hypertension, obesity, central obesity, and dyslipidemia. Obesity has been identified as the most important modifiable risk factor in the aetiology of type-2 diabetes mellitus. Central obesity has been shown to be the most pathogenically important in the causation of metabolic disorders including type-2 diabetes. Aims: To determine the association of central obesity with type 2 diabetes in Bangladeshi women. Subjects and Methods: A total of 60 type 2 diabetic female subjects along with 60 healthy female subjects were recruited in this study. Anthropometric indices were measured using standard techniques. Serum glucose was measured using glucose-oxidase method, insulin was measured using ELISA and thyroid hormones were measured using chemiluminescence based automated Immulite Auto analyzer (DPC, USA). Insulin secretory capacity and insulin sensitivity were estimated using fasting glucose and fasting insulin by HOMA-CIGMA software. Results: Waist circumference of the control (89±8) subjects was significantly (p=0.046) lower than the diabetic (94±11) subjects. Waist-hip ratio of the control subjects was significantly lower compared to diabetic subjects. Fasting plasma insulin level in control sub-jects (7.6±2.2) was significantly (p=0.009) lower compared to diabetic subjects (11.8±9.8). Plasma lipid profile and thyroid hormone status in control and diabetic subjects were not found significantly different. Insulin secretory capacity (HOMA %B) and insulin sensitivity (HOMA%S) in control subjects (93 ±21, 95±39 respectively) were found to be significantly higher com-pared to diabetic subjects (45±32, 67±42 respectively). In age-adjusted binary logistic regression analysis, waist circumference was found to be significantly associated with diabetes. In multiple linear regression analysis TSH was found to be significantly associated with waist circumference. Conclusion: Waist circumference may be an independent indicator for the development type 2 diabetes in Bangladeshi women which may have influenced by thyroid stimulating hormone (TSH). Key Words: waisItem A comparative study of body iron status and lipid profile in acute myocardial infarction patients.(2002-07-25) Sultana, N; Haque, M M; Ali, M S; Begum, B A; Jahan, N; Akter, S; Roy, MThis study was carried out to evaluate the relationship between body iron status and lipid profile in hospital admitted clinically diagnosed AMI patients considering the concept that there is a potential association between body iron status and coronary heart disease (CHD). Total 80 subjects were selected, of which 40 were healthy adults and 40 were AMI patients. Fasting blood samples were collected from healthy adults. Blood samples of AMI patients were collected within 24 hours of the attack of myocardial infarction. Body iron status was measured in term of 3 variables serum total iron concentration, TIBC and transferrin saturation. Lipid profile variables measure were total cholesterol, triglyceride, LDL-cholesterol and HDL-cholesterol. No correlation was found between serum iron and the variables of lipid profile. TIBC was found to maintain negative correlation with total cholesterol, triglyceride and LDL-cholesterol but positive correlation with HDL-cholesterol. Transferrin saturation was found to maintain strongly positive correlation with total cholesterol, triglyceride and LDL-cholesterol but strongly negative correlation with HDL-cholesterol. This correlation of TIBC and transferrin saturation with lipid profile supports the hypothesis that there is a potential association between body iron status and coronary heart disease.Item Correlation between serum bilirubin and serum ferritin Level in thalassaemia patients.(2011) Sultana, N; Sadiya, S; Rahman, M HThalassaemia is the most common hereditary disorder in the world including Bangladesh. Beta thalassaemia major and Hb-E thalassaemia both are common in our country. Iron overload causes most of the mortality and morbidity associate with thalassaemia. To assess the iron over load and liver function a cross sectional comparative study was carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka in collaboration with Thalassaemia Center and Department of Pathology, Dhaka Shishu Hospital, Dhaka during the period of July 2006 to June 2007. The study was carried out with the patients who visited regularly in Dhaka Shishu Hospital Thalassaemia Centre (DSHTC) and had multiple transfusions (more than five) and age more than 2 years. To compare the state of liver function with normal healthy individuals' normal healthy persons were also included. Total 70 subjects were included in this study. The study subjects were distributed into two groups, the group - A (cases, n=40) and group - B (healthy controls, n=30). According to the major types of thalassaemia present in our country, group -A again divided into two, group - AI b-thalassaemia major (n=12) and group - AII of Hemoglobin E b-thalassaemia (n=28). The mean of serum Bilirubin in group - A and group - B were (2.04 ±0.70) mg/dl and (0.67±0.15) mg/dl respectively. Group - A had higher serum bilirubin than group -B in p value <0.001.The mean level of serum bilirubin in group - AI was (1.70±0.70)mg/dl and the mean of bilirubin in group AII was (2.18±0.66) mg/dl. Group -AI had lower serum bilirubin than group AII in p value <0.05. Pearson's correlation between serum bilirubin and serum ferritin had r value -0.26 was statistically not significant. Mean level of serum ferritin in the total was (2729.40 ± 1935.87) ng/ml, minimum level was 304 ng/ml and maximum was 7256ng/ml. Mean level of serum ferritin in the patients of b - thalassaemia major was (4098.67 ± 1598.63) ng/ml, minimum level was 1212ng/ml and maximum was 7560ng/ml. Mean level of serum ferritin in the patients of HbE b - thalassaemia was (2232.57± 1598.63) ng/ml, minimum level was 304ng/ml and maximum was 630ng/ml. Group AI had higher level of serum ferritin than group AII in p value <0.05.Item Cystatin C: A Better Predictor of Kidney Function in Diabetic Patients .(2011) Shima, T S; Khatun, A; Yeasmin, F; Ferdousi, S; Kirtania, K; Sultana, NSerum cystatin C is a new promising marker of renal function. The aim of this study was to analyze serum cystatin C as a better predictor of renal function in diabetic nephropathy. In 60 diagnosed diabetic patients, serum cystatin C and serum creatinine were assessed. Glomerular filtration rate was estimated based on the cystatin C concentration according to Cockcroft- Gault formula and based on serum creatinine concentration according to Larsson formula. DTPA-GFR (Diethylenetriamene pentaacetate Renogram) was done as reference standard. The cross tabulation of DTPA-GFR was done with eGFR- creatinine and eGFRcystatin C. The calculated sensitivity, specificity and accuracy of eGFR- creatinine were 85%, 87.2% and 85% respectively. The eGFR- cystatin C showed higher sensitivity, specificity and accuracy than eGFR- creatinine in studied diabetic subjects. The cystatin C showed more significant correlation, r=0.78, p<0.001 than serum creatinine, r=0.59, p<0.001 with DTPA-GFR in diabetic patients. This study demonstrates that serum cystatin C may be used for early prediction for renal function impairment in diabetic kidney disease.Item Detection of early xerophthalmia by impression cytology and rose Bengal staining--a comparative study.(1992-04-01) Khan, A N; Huda, S; Ahmed, A N; Hossain, T; Sultana, N; Ali, S MTwenty two cases were studied for early detection of Xerophthalmia by impression cytology and Rose Bengal staining. Patients were below 6 years of age and admitted in the paediatric ward of Dhaka Medical College Hospital. Assessment were done by conjunctival impression cytology and staining with 1% Rose Bengal dye. Estimation of serum retinol level was done by HPLC to correlate conjunctival findings with biochemical status. The mean age of the subjects were 3.15 +/- 1.75. Rose Bengal staining was positive in 40% cases and impression cytology was in 60% cases. The mean serum retinol level of the diseased children were 10.5 +/- 3. ug/dl. The sensitivity of Rose Bengal staining was 53.3% and that of impression cytology was 80% in detecting vitamin A deficiency when compared with serum retinol level. The specificity of Rose Bengal staining was 40% and that of impression cytology was 100%. Sensitivity of impression cytology was 100% in patient with retinol level 10 ug/dl.Item High-resolution optical coherence tomography in a case of descemetocele managed with amniotic membrane transplantation(All India Ophthalmological Society, 2018-02) Sultana, N; Chaurasia, S; Ramappa, MAmniotic membrane transplantation is a useful in the management of corneal melts and descemetocele. We describe high-resolution anterior segment optical coherence tomography (OCT) (Optovue) in a patient with descemetocele who was managed surgically with amniotic membrane transplantation. A 60-year-old female presented with a corneal melt in the right eye. She was a case of rheumatoid arthritis and was on systemic treatment with immunomodulators. Slit lamp examination revealed a severe thinning paracentrally. High-resolution OCT was performed at the site of descemetocele. She underwent amniotic membrane transplantation using fibrin glue and bandage contact lens application. At 6 weeks postoperative, the bandage contact lens was removed. The area of thinning healed with scarring. OCT at the healed site revealed stable surface and an increase in stromal thickness to 281 ? this case describes the utility of amniotic membrane in the healing of sterile corneal melts by providing tectonic support and its integration in the stroma. The stromal healing and increased thickness at the site of descemetocele could be delineated on high-resolution OCT imaging.Item Innovative Approaches for Climate-Resilient Farming: Strategies against Environmental Shifts and Climate Change(Ms. M. B. Mondal, 2024-09) Sarma, HH; Borah, SK; Dutta, N; Sultana, N; Nath, H; Das, BC.Climate change, driven predominantly by human activities such as burning fossil fuels and deforestation, is causing significant alterations to global weather patterns. This phenomenon results in more frequent and severe weather events, including prolonged droughts, intense rainfall, and shifting temperature regimes. Such changes pose a substantial threat to agriculture, a sector highly dependent on stable climatic conditions. Crop yields are increasingly unpredictable due to these extreme weather events and shifting growing seasons, impacting food security and livelihoods worldwide. To address these challenges, climate resilience agriculture has emerged as a pivotal solution. This approach involves adopting farming practices and technologies designed to withstand and adapt to changing climatic conditions. Strategies include diversifying crop varieties, precision agriculture, climate smart agriculture, nano biochar application, coated fertilizer applications, natural farming, site specific nutrient management, mulching, precise water management, seed bombing, direct seeding in rice, implementing soil conservation methods etc. Additionally, climate resilience agriculture promotes the integration of traditional knowledge with modern scientific advancements to enhance ecosystem robustness and productivity. By fostering adaptive capacity and reducing vulnerability, climate resilience agriculture aims to safeguard food systems and sustain agricultural productivity in the face of ongoing climate disruptions.Item Iron Status in Pre-Eclampsia: A Case-Comparison Study.(2012) Sultana, R; Ahmed, S; Sultana, N; Karim, S M FazlulPreeclampsia is one of the most leading causes of maternal mortality in developing countries. Many studies have demonstrated the relation between alteration of iron status and preeclampsia. The aim of the study was to assess the status of iron in preeclampsia. This case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in the third trimester of pregnancy attending the Obstetrics & Gynaecology Department of Dhaka Medical College Hospital were selected purposively as study subjects. Among them 50 diagnosed cases of preeclampsia were selected as cases and 50 normal healthy pregnant women as controls. Serum ferritin and serum iron concentration were measured in all study subjects. The mean serum ferritin concentration in cases and controls were 95.06±50.07 μg/l and 45.56±27.44 μg/l respectively. Mean serum iron concentration in cases was 121.78±41.93 μg/dl and that in controls was 61.04±24.18 μg/dl. The present study showed significant differences of mean serum ferritin and serum iron between cases and controls. The study revealed presence of significantly higher level of serum ferritin and serum iron in preeclamptic group.Item Lipoma of Tongue: a case report.(2015-07) Sikder, M A; Mohibullah; Sultana, NLipoma is the benign tumor occurring at any anatomical site where fat is present. It may be evident for 1 to 5 percent of the entire benign tumor of the oral cavity. Lipoma of the tongue is extremely rare because tongue is totally devoid of fat cell. In this case study we report a case of lipoma of tongue. A 45 years old Bangladeshi female patient presented with this benign tumor at the left lateral border with dorsal and ventral surface of the tongue for which complete tumor excision was done.Item Microalbuminuria as a Predictor of Short-Term Mortality in Acute Ischemic Stroke.(2012) Chowdhury, J; Sultana, N; Ahmed, S; Rahman, M M; Akter, M; Rafique, TStroke is one of the major causes of morbidity and mortality all over the world. Microalbuminuria is one of the predictors of mortality. Available published data has suggested that microalbuminuria is a potential new risk factor for ischemic stroke. This study was carried out in the Department of Biochemistry, Dhaka Medical College during the period from July 2009 to June 2010. In this study, we enrolled 120 patients of ischemic stroke. 60 of them were with microalbuminuria (MA) and 60 were without MA. Among the MA +ve group, 38 (63.3%) were males and 22 (36.7%) were females. On the other hand those belonging to MA -ve groups 52 (36.7%) were males and 8 (13.3%) were females. Age range of the subjects in MA +ve group was 45-70 years and in MA-ve group was 50-70 years. In patients with microalbuminuria mortality was 26.7% and in patients without MA mortality was 11.7% (p<0.05). The study showed significantly higher mortality in patients with microalbuminuria than that of the patients without microalbuminuria.Item Outcome of pregnancy in women 35 years of age and above.(2009-01-03) Jahan, M K; Shafiquzzaman, M; Nahar, K; Rahman, M; Sultana, N; Rahman, M M; Begum, RPregnancy outcome among women in the age group of 35 years and more are considered to be less favorable than those of younger women. To observe those, this case control study was conducted in the department of Obstetrics & Gynaecology, Mymensingh Medical College Hospital during the period of 1st June 2003 to 31st May 2004. The study includes 100 patients of 35 years of age or above and 100 controls of 20-30 years of age. Observed complications during the pregnancy and delivery were increased incidence of placenta previa, malpresentation, intrauterine death, preterm labour, obstructed labour ruptured uterus etc. Pregnancy related complications were found significantly high (p<0.001) in case group (80%) compared to control group (51%). Rate of caesarian section was also more among the cases. Post delivery maternal complications were more in case group (53%) compared to control (30%) (p<0.001). Perinatal morbidity and mortality was significantly high. Cause of late fetal death in older women include, failure of the uterine vasculature in older women to adapt sufficiently to the increase haemodynamic demands of pregnancy, reduced fetal oxygenation with maternal age and also a rise in the frequency of preexisting hypertension with age. Maternal age is an important and independent risk in pregnancy outcome.Item Performance of Plasma B-Type Natriuretic Peptide as a Diagnostic Biomarker in Heart Failure.(2011) Hoque, M M; Shafiullah, S; Sultana, P; Sultana, NBackground: Accurate diagnosis of heart failure (HF) is essential for its proper management and logical drug therapy to reduce morbidity and mortality. On this perspective researcher are in search of a good biomarker as complementary to the clinical parameters to improve the performance of HF diagnosis. B-type natriuretic peptide (BNP) secreted by cardiac ventricles in HF has emerged as a new promising biomarker in this regard. Objective: To evaluate the performance of plasma BNP as a diagnostic biomarker in HF. Methods: In a cross sectional study 180 clinically suspected HF patients were selected. Their plasma BNP were measured and then subjected to echocardiogram. Patients were categorized as HF and without HF on the basis of echocardiogram and against this information the performance of plasma BNP of study subjects were evaluated as a diagnostic biomarker of HF considering 100 pg/ ml as its cut off point. Results: Sensitivity, specificity, accuracy, PPV, NPV, PLR and NLR of plasma BNP for diagnosis of HF found to be 88 %, 63.8 %, 77.2 %, 75.2 %, 81.0 %, 2.4 and 0.2 respectively. Conclusion: Plasma BNP concentration increases in HF. Based on 100 pg/ml as cut off point, plasma BNP shows good performance in diagnosis of HF.Item Prevalence of Metabolic Syndrome in Newly Diagnosed Type 2 Diabetes Mellitus.(2011) Nahar, S; Rahman, M Z; Ullah, M; Debnath, B C; Sultana, N; Farhad, C M R QBackground- People with metabolic syndrome are twice as likely to die from, and three times as likely to have a heart attack or stroke compared with people without the syndrome. People with metabolic syndrome have a five-fold greater risk of developing type 2 diabetes. We investigated the prevalence of metabolic syndrome in patients with newly diagnosed diabetes mellitus. Methods- It was a cross sectional study. The study was conducted in Department of Biochemistry, Sylhet MAG Osmani Medical College, Sylhet & Diabetic Hospital, Sylhet. The study was conducted From July 2008 to June 2009 among 200 patients with newly diagnosed type 2 diabetic patients with age >20 years. Along with blood glucose, different components of metabolic syndrome was assessed, i.e. serum triglyceride level, serum HDL level, blood pressure and waist circumference. Results- Prevalence of metabolic syndrome was 73.5% according to NCEP-ATP III criteria, 81.0% according to modified NCEP-ATP III criteria, 82.5% according to modified WHO criteria and 61.0% according to IDF criteria. All variables other than waist hip ratio and fasting blood sugar had statistically significant higher mean values among patients with metabolic syndrome than patients without metabolic syndrome. Conclusion- It may be concluded that prevalence of metabolic syndrome is considerable in newly diagnosed type 2 diabetic patients in our population. The considerable prevalence of metabolic syndrome in our population is implicative of an alarming risk of cardiovascular disease in future.Item A rare case of Mayer-Rokitansky K黶ter-Hauser syndrome with ectopic kidney(Medip Academy, 2024-12) Shil, KK; Mahrukh, H; Ferdousi, T; Banu, H; Sultana, N; Hasanat, MA.Mayer-Rokitansky K黶ter-Hauser (MRKH) syndrome is a congenital anomaly of female reproductive system and is the second most common cause of primary amenorrhea. Utero-vaginal agenesis also may be associated with different other congenital anomalies and mostly involve the renal and skeletal system. Karyotyping and gonadal development are normal. So, patient抯 anthropometric measurement, secondary sexual characteristics and hormonal profile are usually normal. Transabdominal sonography and MRI can confirm the absence of uterus, cervix and upper part of vagina, as well as can identify another associated congenital anomaly. We report the case of 25-year-old women presented with primary amenorrhea and normally developed secondary sexual characteristics with normal external genitalia. Transabdominal sonography and MRI revealed agenesis of uterus, normal ovary and ectopic right kidney. MRKH syndrome with ectopic kidney is a rare form of mullerian agenesis.Item Role of Serum Total PSA (Prostate Specific Antigen) and Free to Total PSA Ratio in the Diagnosis of Carcinoma Prostate.(2011) Ferdousi, S; Alim, M A; Ferdous, Z; Khatun, A; Sultana, N; Shahnaz, A; Hossain, M SThe objective of the study was to evaluate and compare the role of total and free/total ratio of serum prostate specific antigen level in diagnosing carcinoma prostate. A cross sectional study was conducted at the Department of Biochemistry, Dhaka Medical College (DMC) with collaboration of the Department of Urology, Dhaka Medical College Hospital (DMCH), Dhaka from July 2008 to June 2009. This study was carried out on 60 patients above 50 years of age who attended the Department of Urology, Dhaka Medical College Hospital, complaining of irritative or obstructive lower urinary tract symptoms (LUTS) suspected as clinically benign prostatic hyperplasia (BPH) or cancer prostate. It was aimed to assess the role of total and free/total ratio of serum PSA in diagnosis of BPH and carcinoma prostate with reference to histological diagnosis. All the cases were evaluated by history, physical examination including digital rectal examination, serum prostate specific antigen level, transabdominal/ trans-rectal ultra- sonogram. From all patients, blood sample were collected before digital rectal examination or any per urethral manipulation. Final diagnosis was obtained by histo-pathological examination, specimen being obtained by perrectal biopsy with biopsy-gun. Histopathological examination detected prostate cancer in 20 out of 60 patient and 17 of these Cap 20 have a total PSA 4 ng/ml and only 3 have total PSA 4 ng/ml. 18 of these 20 have free to total ratio 0.16 and 02 have f/t ratio 0.16. Among 60 patients, 40 patients were detected BPH on histopathological diagnosis. 20 of these BPH patient have tPSA 4 ng/ml and 20 of BPH have tPSA 4 ng/ml. 38 of 40 BPH patient have f/t ratio>0.16 and 2 of 40 patient are f/t ratio 0.16. Receiver operating characteristic analysis indicated a threshold f/t ratio 0.16 was optimum discriminatory level. The sensitivity of total serum PSA (at cut off value of>4 ng/ml) in correctly differentiating prostatic carcinoma of those who have the condition is 85%, while the specificity of the test in correctly detecting those who do not have the disease is 50%. The PPV is 45.9%, NPV is 87% and accuracy is 61.7%. The sensitivity of free/total serum PSA (at cut off value of 0.16 ng/ml) in correctly differentiating prostatic carcinoma from BPH is 90%, while the specificity of the test in correctly detecting those who do not have prostatic carcinoma is 95%. The PPV of the test is 90% and the NPV of the test is 95%. The overall accuracy of the test is 93.3%. This study showed significant difference of total and free/total ratio of serum prostate specific antigen (PSA) in differentiating benign prostatic hyperplasia (BPH) from carcinoma prostate. Receiver operating characteristic curves showed advantage for the f/t PSA ratio when compared with total PSA in detecting prostate cancer. From the study it may be concluded that total and f/t ratio of prostate specific antigen (PSA) is a useful marker in diagnosis of carcinoma prostate. Free/total ratio is more accurate than total PSA.Item Serum and Erythrocyte Magnesium levels in Offsprings of Essential Hypertensive Parents.(2012) Ferdousi, S; Sultana, N; Rahman, M H; Haque, R; Khanam, M; Howlader, M H; Arslan, M IHypertension is an important public health challenge worldwide, 95% of which are primary or essential hypertension, where the exact causes are not known. It has been thought that magnesium level has an association with hypertension and plays role in the pathogenesis of essential hypertension. Several evidences suggested that decreased magnesium level may be a significant modifiable risk factor for developing essential hypertension. To explore the relationship between serum and erythrocyte magnesium level with blood pressure, this case control study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), during the year 2006. Thirty offsprings of essential hypertensive parents were taken as cases and 30 age and sex-matched offsprings of normotensive parents were taken as controls. Serum & erythrocyte magnesium were measured by colorimetric Calmagite method. Significantly lower serum magnesium level (mg/dl) was found in cases than that of controls (1.90±0.210 vs 2.13±0.366, p<0.01) and erythrocyte magnesium (mg/dl) was also found to be lower in cases when compared with that of controls (4.46±0.699 vs 5.43±0.775, p<0.001). Mean systolic and diastolic blood pressure were found to be significantly higher (p<0.01) in cases as compared to controls. Though it is difficult to draw any definite conclusion, it may be assumed that, a hereditary predisposition to hypertension may be related to magnesium metabolism and magnesium deficiency might have a role in the future development of hypertension in the offsprings of essential hypertensive parents.Item Serum calcium and lipid profile in acute ischemic stroke.(2015-07) Sharmin, N; Sultana, N; Mazumder, P; Rahman, TBackground: Worldwide acute ischemic stroke (AIS) is a major public health problem. Therefore, this study was undertaken to see the association of some biochemical risk factors with AIS in Bangladesh. Methodology: This study was conducted in Biochemistry department of Dhaka Medical College, Dhaka from January 2014 to December 2014. In this study, 50 patients of AIS considered as case and 50 age and sex matched healthy individuals taken as control. Blood sample was collected and tested for serum calcium and lipid profile in case and control. All the parameters then compared statistically between two groups. Results: Study showed that serum calcium was significantly lower (p= 0.001) in cases and serum TChol, TAG, LDL-C significantly higher (p= 0.035, 0.001 and 0.019 respectively) and HDL-C significantly lower (0.001) in cases compared to controls. Conclusions: This study concludes that low serum calcium level and altered lipid profile are significantly associated with AIS.