Browsing by Author "Mamadou, S."

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    Antisickling effects of hydroethanolic extract of Oxytenanthera abyssinica leaves
    (?Eldaghayes Publisher, 2025-06) Mbaye, S; Ibrahima, D; Awa, B; Fatoumata, B; Khadim, FC; Absatou, D; Oumy, KM; Mamadou, S.
    Background: Sickle cell disease is a hereditary hemoglobinopathy. It is characterized by the presence of abnormal hemoglobin S levels at high concentrations in red blood cells. Aim: This study aimed to investigate the potential of a hydroethanolic extract from Oxytenanthera abyssinica (AO) leaves to inhibit red blood cell sickling in individuals with sickle cell trait (HbAS) and sickle cell disease (HbSS). Methods: Ten grams of powdered AO leaves were macerated in 100 ml of a 60% hydroethanolic solution. Following filtration, the macerate was concentrated using a rotary evaporator until a dry crude extract was obtained. The dry extract was reconstituted in water to prepare three test solutions at concentrations of 2.5 and 1.25 mg/ml. Emmel tests were performed by incubating these extract solutions with blood samples obtained from individuals with sickle cell trait (HbAS), sickle cell disease (HbSS), and healthy controls (HbAA). The percentage of sickled red blood cells was determined using optical microscopy. Results: The hydroethanolic extract of AO leaves significantly reduced the percentage of sickled red blood cells in individuals with sickle cell trait (HbAS) and sickle cell disease (HbSS). The antisickling effect exhibited a dose- dependent relationship. Conclusion: Our findings indicate that the crude hydroethanolic extract of AO leaves has significant antisickling activity. This suggests a potential source of bioactive molecules for the development of low-cost therapeutic interventions against sickle cell disease.
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    Evaluation of the In-vivo Antiparasitic Effects of the Aqueous Extract of the Leaves of Alchornea Cordifolia (AEAC)(Euphorbiaceae) as an Alternative in Poultry Farming in Côte d'Ivoire
    (Ms. M. B. Mondal, 2025-06) Grace, KG; Bertin, YK; Shcherazade, O-SF; Rivière, AK; Cyprien, YB; Mamadou, S.
    Coccidiosis is a major parasitic disease affecting chickens and is a significant factor in the decline of their zootechnical performance. Conventional control methods rely on synthetic anticoccidial drugs, which pose risks to both animal and human health. This has prompted growing interest in natural alternatives, particularly medicinal plants. Alchornea cordifolia, a plant native to Côte d'Ivoire and widely used in traditional medicine, is known for its diverse therapeutic properties. Phytochemical screening of the aqueous leaf extract revealed the presence of sterols, polyterpenes, polyphenols, quinones, alkaloids, and catechic tannins. The LD??, determined in accordance with OECD guideline 423, indicated that the extract is non-toxic at doses of 2000 and 5000 mg/kg body weight in Wistar rats. The study evaluated the effects of A. cordifolia aqueous extract on weight gain, feed conversion ratio, lesion scores, and clinical appearance in broiler chickens. The results showed no adverse impact on zootechnical performance. Furthermore, the extract demonstrated anticoccidial efficacy against Eimeria-induced coccidiosis. After seven days of treatment, oocyst counts dropped significantly across the three experimental groups: from 102,300 to 200 OPG in the control group (treated with a conventional anticoccidial), from 86,350 to 4,200 OPG in the group treated with 5 g/L of the extract, and from 21,400 to 3,500 OPG in the group treated with 10 g/L. These results suggest that A. cordifolia leaf extract exhibits promising anticoccidial activity and may be considered as a potential alternative in poultry health management.