Browsing by Author "Gupta, S K"

Now showing 1 - 20 of 370
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    Abdominal compartment syndrome--an old syndrome, a new perspective.
    (2007-10-18) Puneet,; Chauhan, V; Singh, S; Gupta, S K; Shukla, V K
    The abdominal compartment syndrome is a life threatening condition resulting from pathologic elevation of the intraabdominal pressure. Prompt diagnosis is required to avoid significant sequelae. Diagnosis of this syndrome is based on clinical findings and intra abdominal pressure monitoring. Treatment consists of decompressive laparotomy, which corrects the pathology. Various surgical techniques are described to manage the open abdomen. Despite considerable attention accorded to this disorder, it is still associated with high morbidity and mortality. This review article deals with the identification of risk factors, pathophysiology, diagnostic criteria and treatment of critically ill patients with the abdominal compartment syndrome.
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    Abdomino-scrotal hydrocele (a case report).
    (1988-07-01) Gupta, S K; Shukla, V K; Roy, S K
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    Acid fast bacilli in lymph node aspirate and smears from ear lobules and fingers in long treated patients.
    (1984-01-01) Kumar, B; Kaur, S; Gupta, S K; Rajwanshi, A; Darshan, H
    Skin slit smears from fingers and ear lobules and lymph node aspiration smears stained with Ziehl-Neelsen stain were studied in 43 patients of LL or BL disease. All the patients had taken dapsone monotherapy for 3-7 years. None of the patients had clinical evidence of dapsone resistance. Small number of bacilli were detected in 16 patients. Lymph node aspirate was positive in 5 cases, whereas ear lobule and fingers yielded bacilli in 12 and 13 cases respectively. It is recommended that in addition to the traditional ear lobe it is imperative to study other sites as well. Study from fingers is recommended for the sake of simplicity. Where facilities are available sampling of the lymph node may also be attempted to advantage.
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    Acridine orange stain--a rapid method for diagnosis of neonatal septicemia.
    (1989-02-01) Gupta, S K; Sharma, U; Gupta, M L; Sharma, D K
    The present study included 150 newborns; 100 clinically septic and 50 clinically aseptic who served as control. Out of 100 clinically septic newborns, blood culture was positive in 33 (33%), serum CRP was positive in 64 (64%) and acridine orange stained buffy coat smear was positive in 76 (76%). Serum CRP was found to be the most specific (specificity 96%) and acridine orange stained buffy coat smear examination the most sensitive (sensitivity 94.3%) test for diagnosis of neonatal septicemia.
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    Acute and chronic toxicity studies of DDT in albino rats.
    (1971-02-01) Kashyap, S K; Gupta, S K
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    Acute Disseminated Encephalomyelitis
    (2005-01) Gupta, S K; Gupta, Ajay; Mahajan, Annil; Verma, Sourabh; Singh, J B
    Acute disseminated encephalomyelitis is a multifocul inflammatory myelinopathy of the CNS which is generally but not exclusively monophasic. Typically it follows after vaccination or some viral infection. The diagnosis is difficult due to insensitivity of CT imaging and lack of pathognomic clinical and laboratory features. We highlight the role of MRI in diagnosing an unusual case of ADEM presenting to us with fever, seizures, hemiparesis and drowsiness who improved remarkably with methyl prednisolone therapy.
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    Acute oral toxicity of hexachlorocyclohexane (BHC) in albino rats.
    (1976-05-01) Kashyap, S K; Gupta, S K; Bhatt, H V; Shah, M P
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    Adenosine deaminase activity in pleural fluid.
    (1987-02-01) Gupta, S K; Mitra, K
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    Advances in pharmacological strategies for the prevention of cataract development.
    (2009-05-23) Gupta, S K; Selvan, V Kalai; Agrawal, S S; Saxena, Rohit
    Cataractous-opacification of the lens is one of the leading causes of blindness in India. The situation can be managed by surgical removal of the cataractous lens. Various pharmacological strategies have been proposed for the prevention and treatment of cataract. Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients. This review deals with the various mechanisms, and possible pharmacological interventions for the prevention of cataract. The article also reviews research on potential anticataractous agents, including aldose reductase inhibitors, glutathione boosters, antiglycating agents, vitamins and various drugs from indigenous sources.
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    Agenesis of gall bladder.
    (1983-11-01) Sharma, O P; Vaidya, M P; Gupta, S K
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    Agranulocytosis following isoniazid. Report of a case.
    (1973-05-01) Mehrotra, T N; Gupta, S K
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    Alcaligenes fecalis septicemia.
    (1983-11-01) Desai, N; Gupta, S K; Menon, R K; Seth, V
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    Aluminium Phosphide Poisoning: A Challenge for the Physician
    (2001-01) Verma, Vijay Kumar; Gupta, S K; Parihar, Ashok
    Acute Aluminium Phosphide ( ALP ) Poisoning by insalational or ingestional exposure is seen world wide. Except in Morocco, Denmark and India, nowhere in the world, it is ingested for deliberate self-poisoning ( DSP ), The rural belts of North states of India are worst affected with high and variable mortality rates in the young population with male dominance. The poison affects all systems; the shock, carding arrhythmias wityh varied electrocardiograph (ECG ) changes and gastrointestinal (GIT ) features being the most prominent. The role of magnesium sulphate (Mg So4) in reducing the cardiac arrhythmias and mortality is well documented and the problem needs multi-faceted approach in the form ofpreventive measures, strengthening ofmedical-aid services at gross root levels, stringent restricitions on supply of ALP in open market, updating the management techniques and overall a search for an antidote.
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    An aminopeptidase regulates LPS stimulated interleukin-8 receptor on the surface of human neutrophils.
    (1997-02-01) Bhattacharya, C; Manna, S K; Samanta, S; Gupta, S K; Samanta, A K
    A large number of inflammatory diseases are mediated by interleukin-8, an inflammatory neutrophil chemotactic agent. Since the cytokine acts through a cell surface receptor, detailed knowledge about the regulation of receptor expression is very important. We found that LPS in serum became activated and triggered the expression of IL-8 receptor by more than two folds within 30 min. After that period, the receptor attained normal level within 2 hr of SA-LPS stimulation. EDTA and bestatin could block this downregulation of IL-8 receptor. Intracellular Ca2+ level was increased till 45 min of SA-LPS stimulation and then the level was reduced. Addition of CaCl2 accelerated and depletion of Ca2+ inhibited the downregulation of the IL-8 receptor. The ligand could fully protect the loss of receptor from downregulation. It suggests that during SA-LPS stimulation, increase in intracellular Ca2+ level activates an aminopeptidase which presumably cleaves the N-terminal region of the receptor, critically essential for the function of IL-8. Thus the activated aminopeptidase regulates the functions of IL-8. The study is important for understanding the regulation of IL-8 receptor expression by LPS during bacterial infection.
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    Anaesthetic and intensive care aspects of spinal injury.
    (2001-03-17) Grover, V K; Tewari, M K; Gupta, S K; Kumar, K V
    Over the last few years, spinal injuries have been classified depending upon their causative mechanism and on the basis of three column concept of the structure of vertebral column. The concept of primary and secondary injury has laid more stress on prevention and treatment of secondary injury. Methyl prednisolone still remains the drug of choice for prevention of secondary injury. Spinal injury involves all organ systems of the body depending on the level of lesion. Immobilisation of injured spine and maintenance of adequate airway after spinal injury need immediate attention. Orotracheal intubation under general anaesthesia, with manual in-line traction, is still considered the best method. Hypotension, hypertension and hyperglycaemia should be avoided during anaesthesia. Care should be taken to avoid effects of autonomic hyper reflexia. Spinal cord functions should be monitored and, if required, induced hypotension can be used with adequate monitoring.
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    Anterior surgical approaches to the sub-axial cervical spine.
    (2000-03-07) Khosla, V K; Gupta, S K; Sharma, B S; Mathuriya, S N
    Anterior cervical spine surgery has come of age, as a golden route for treating anteriorly placed cervical compressions ranging from simple prolapsed disc to long segment pathologies like ossification of posterior longitudinal ligaments and cervical spondylotic myelopathy. Numerous technical modifications of the procedure are described. The role of stabilisation established for several pathologies, is still debateable in surgery for cervical disc. Bone is the ideal tissue for fusion. Hydroxyapetite implants are goods, but costly for our set up. Methylmethacrylate has a limited role in elderly patients with malignancy and a short life expectancy. Anterior cervical instrumentation has mushroomed over the last decade. Acceptable as methods of immediate stabilisation, the choice of the system varies with the surgeon. The authors use simple titanium plates with locking screws for the purpose.
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    Anti-inflammatory activity of sodium pyruvate--a physiological antioxidant.
    (2000-01-05) Gupta, S K; Rastogi, S; Prakash, J; Joshi, S; Gupta, Y K; Awor, L; Verma, S D
    The anti-inflammatory activity of sodium pyruvate was evaluated in acute and chronic models of inflammation in rats. Oral administration of sodium pyruvate at three different dose levels of 125, 250 and 500 mg/kg body weight significantly inhibited the carrageenan induced acute paw edema in a dose dependent manner. The effect of 500 mg/kg sodium pyruvate was comparable to that of 12.5 mg/kg of standard diclofence. In Freund's adjuvant arthritis model, oral administration of sodium pyruvate at the submaximal dose of 250 mg/kg once daily upto one week before Freund's adjuvant injection and immediately by the same route on the 7th day of adjuvant injection significantly reduced the edema at 18 hours after the challenge. The treatment was continued for 14 days thereafter in two divided doses of 125 mg/kg in the morning and 125 mg/kg in the evening. Sodium pyruvate showed significant anti-inflammatory activity at the 14th day (chronic phase) also. To conclude, sodium pyruvate exhibited significant anti-inflammatory activity in both the models of inflammation which could be attributed to its antioxidant properties.
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    Anti-inflammatory activity of the oil isolated from Cyperus scariosus (R. Br.).
    (1972-01-01) Gupta, S K; Sharma, R C; Aggarwal, O P; Arora, R B
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    Anti-inflammatory studies on a crystalline steroid isolated from Commiphora mukul.
    (1972-06-01) Arora, R B; Taneja, V; Sharma, R C; Gupta, S K