Browsing by Author "Arora, Sandeep"

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    Bullous auto erythrocyte sensitization syndrome in alcohol dependence.
    (2013-03) Arora, Sandeep; Arora, Gulhima; Gupta, Anindya K; Singh, Gurdeep
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    Cutaneous reactions in nuclear, biological and chemical warfare.
    (2005-03-06) Arora, Sandeep
    Nuclear, biological and chemical warfare have in recent times been responsible for an increasing number of otherwise rare dermatoses. Many nations are now maintaining overt and clandestine stockpiles of such arsenal. With increasing terrorist threats, these agents of mass destruction pose a risk to the civilian population. Nuclear and chemical attacks manifest immediately while biological attacks manifest later. Chemical and biological attacks pose a significant risk to the attending medical personnel. The large scale of anticipated casualties in the event of such an occurrence would need the expertise of all physicians, including dermatologists, both military and civilian. Dermatologists are uniquely qualified in this respect. This article aims at presenting a review of the cutaneous manifestations in nuclear, chemical and biological warfare and their management.
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    Doctor I am on fire: eosinophilic folliculitis in HIV negative.
    (2009-03-19) Suresh, M S; Arora, Sandeep; Nair, R R K
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    Evaluation of Phenolic contents and Antioxidant potential of Murraya Koenigii (L) spreng roots.
    (2012-11) Sindhu, Rakesh K; Arora, Sandeep
    The present study was to evaluate the antioxidant potential of ethanol extract from roots of Murraya koenigii. Ethanol extract of roots was used to study their total phenolic and flavonoid contents and antioxidant including radical scavenging of 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide. The ethanol extract showed significant results, Total phenolic contents were estimated to be equivalents to 51.23 ± 2.53mg of gallic acid equivalent and total flavonoid contents were 43.58 ± 1.89mg of catechin/g equivalent. The percentage of DPPH and NO scavenging activity increased with increasing various concentration of extract.
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    Fractional CO2 laser with topical 1% terbinafine cream versus oral itraconazole in the management of onychomycosis: A randomized controlled trial
    (Scientific Scholar, 2023-02) Ranjan, Eeshaan; Arora, Sandeep; Sharma, Neha
    Background: Onychomycosis accounts for 20–40% of all nail disorders. It is difficult to cure with resistance to anti-fungal drugs, their side effects and drug interactions limiting treatment options. Itraconazole is a widely accepted oral medication used for onychomycosis while fractional CO2 laser along with a topical anti-fungal has shown promising results for nail plate clearance in onychomycosis. Aim: To compare the efficacy of fractional CO2 laser with 1% terbinafine cream versus itraconazole in the management of onychomycosis. Methods: A prospective, randomised, single-centre, two-arm, parallel-group interventional study was conducted at Command Hospital Air Force, Bangalore. Onychomycosis cases confirmed by KOH mount/culture-positive were included. Patients were randomly divided into two groups. Group A received 4 sessions of fractional CO2 laser every fourth week with twice-daily application of 1% terbinafine cream; Group B received one-week pulse therapy with capsule itraconazole once every four-week for three pulses. The response was assessed by Onychomycosis Severity Index, a validated onychomycosis assessment scale, at baseline and at six months. Results: Group A had 50 patients with a total of 98 nails. Clinical improvement was seen in 83/98 (84.7%) nails. The average reduction in Onychomycosis Severity Index was 8.65 (P < 0.05). Group B had 50 patients with a total of 136 nails. Clinical improvement was seen in 104/136 (76.5%) nails. The average reduction in Onychomycosis Severity Index was 7.37 (P < 0.05). Both groups showed statistically significant improvement measured by ‘Reduction in Onychomycosis Severity Index’ at six months; however, there was no significant difference between the two arms. Limitations: The main limitations of the study are the small sample size and lack of long-term follow-up to assess recurrence of infection. Conclusion: Fractional CO2 laser with 1% terbinafine cream is an effective and safe method for inducing nail clearance in onychomycosis and has efficacy similar to itraconazole pulse therapy.
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    Hand foot and mouth disease: emerging epidemics.
    (2008-09-05) Arora, Sandeep; Arora, Gulhima; Tewari, Vanmalini
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    Idiopathic CD4 lymphocytopenia presenting as recurrent giant molluscum contagiosum.
    (2013-07) Arora, Sandeep; Arora, Gulhima; Sahai, Kavita; Borde, Priyanka
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    Reiter's disease in a six-year-old girl.
    (2005-07-06) Arora, Sandeep; Arora, Gulhima
    Reiter's syndrome has characteristically been described in young males and presents with a triad of urethritis, conjunctivitis and arthritis. Reiter's syndrome has been known to affect children, although they usually do not manifest with the typical triad. Only a few such cases have been reported and these have described males predominantly. A case of a six-year-old girl who presented with watery diarrhea, redness of eyes and joint pains followed by skin involvement is reported. She was managed with topical salicylic acid and hydrocortisone, and oral aspirin and showed complete resolution of her clinical features in three weeks.
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    Relapsing linear acantholytic dermatosis in a four-year-old boy.
    (2005-09-06) Arora, Sandeep; Arora, Gulhima; Ranjan, P
    Linear acantholytic dermatoses are a spectrum of cutaneous disorders that form a subset of linear dermatoses with distinct clinical features and histopathologically show acantholysis. The lesions may be zosteriform or follow the lines of Blaschko. This report describes a four-year-old boy who, on a follow up of two years, exhibited a relapsing acantholytic dermatosis along the lines of Blaschko. Histopathology of a representative lesion revealed epidermal acantholysis with multiple acantholytic keratinocytes with in the prickle cell layer and an absence of corp ronds and grains, consistent with features of Hailey-Hailey disease. This, to our knowledge, is the third case of relapsing linear acantholytic dermatosis reported.
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    Undiagnosed purpura: a case of autoerythrocyte sensitization syndrome associated with dermatitis artefacta and pseudo-ainhum.
    (2006-09-20) Sawhney, M P S; Arora, Gulhima; Arora, Sandeep; Prakash, Jyoti
    A 23-year-old young woman presented with recurrent episodes of painful bruising along with linear erosions on the accessible areas of the body of nine years duration with a pseudo-ainhum of her left nipple for the past three months. Her case history included repeated visits to various physicians at different centers and an extensive investigative profile. A diagnosis of autoerythrocyte sensitization was made on the basis of the clinical history, dermatological examination complemented by a positive autoerythrocyte sensitization test, psychiatric evaluation and absence of any organic cause for her ailment. She was placed on psychiatric management and has remained symptom-free after six months follow-up. The case is reported for its rarity, as well as for the association of autoerythrocyte sensitization syndrome with frank dermatitis artefacta and pseudo-ainhum, which to the best of our knowledge has not yet been reported in the literature.