Browsing by Author "Arora, S K"
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Item Acute cerebellar ataxia: an unusual presentation of poliomyelitis.(1990-06-01) Gupta, P C; Gathwala, G; Aneja, S; Arora, S KItem AIDS in India: a report of three cases with review of literatures.(1988-06-01) Sehgal, S; Arora, S K; Rajwanshi, A; Deodhar, S DSera from 3500 individuals including patients of non-Hodgkin's lymphoma, patients with sexually transmitted diseases, leprosy, jail inmates, healthy laboratory workers and patients on hemodialysis were screened for antibodies against human immunodeficiency virus (HIV) as a sero surveillance exercise of one of the centers set up by the India Council of Medical Research at the Postgraduate Institute of Medical Education & Research, Candigarh. Three individuals were found to be strongly positive by ELISA using the Wellcozyme kit, with no background noise in the population studies. These three patients were also evaluated by the Western blot technique and showed strong antibody reaction to all the major gene products. It was also possible to ascertain the approximate incubation period of infection in a case who rapidly developed full blown AIDS and died of wasting syndrome. Comprehensive data of 14 cases was also collected from all the centers in India and in every case one could trace the contact outside India. None of the 3 cases studied at our center had Kaposi's sarcoma. These observations could be important landmarks in the epidemiology of AIDS in India.Item Alcaptonuria--2 cases.(1983-10-01) Chaudhary, H R; Gokhroo, R K; Arora, S K; Bhardwaj, B; Bhati, R S; Mathur, M SItem Bcl2 and ROS1 expression in human meningiomas: an analysis with respect to histological subtype.(2005-07-10) Girish, V; Sachdeva, N; Minz, R W; Radotra, B; Mathuria, S N; Arora, S KTumors of the central nervous system account for approximately 9% of all primary neoplasm in humans, while tumors of covering elements, the meninges, account for 13-19% and constitute the second largest group of brain tumors. These are known to exhibit a variety of chromosomal abnormalities besides change in the expression level of certain oncogenes. Among oncogenes, bcl2, an anti-apoptotic factor and ROS1 that encodes a protein with a structure similar to the epidermal growth factor (EGF) and insulin receptor and has a tyrosine kinase activity, have been shown to be associated with many malignant tumors. In the present study we have analysed the expression of bcl2 using immuno-histochemistry and ROS1 expression by reverse-transcription coupled with polymerase chain reaction (RT-PCR) of the transcript using primers specific for the intra-cellular domain and then tried to correlate the findings with the subtype of the meningioma defined on the basis of histology. Out of the six bcl2 positive cases in our study, there were three transitional tumors, two fibroblastic and one recurrent meningioma subtype. bcl2 seemed to be more consistently expressed in the cytoplasm of spindle cell component of meningiomas. Thirteen meningiothelial meningiomas did not show any staining for bcl2. ROS1 gene expression could be detected in 4 tumors all of those were Grade-I meningothelial meningiomas. One of the malignant meningioma included in the study was clearly negative for bcl2 as well as ROS1. Thus bcl2 and ROS1 oncogene expression in meningiomas are not concurrent and neither can be ascribed to any histologic subtype or grade of tumor.Item Calcification of ulnar nerve in leprosy--a case report.(1989-01-01) Arora, S K; Mukhija, R D; Mohan, L; Girdhar, M; Matreja, V S; Saxena, R; Sharma, S PA case of Tuberculoid leprosy who had taken irregular treatment for five years and had thickened ulnar nerve which on radiological examination showed calcification, is reported.Item Cephalexin in respiratory tract infections--a clinico-microbiological study.(1972-09-01) Gulati, P D; Arora, S K; Bhatia, V N; Natarajan, R; Kulpati, D D; Vaishnava, HItem Changing phage pattern of Staphylococcus in pyoderma cases.(1990-10-01) Baslas, R G; Arora, S K; Mukhija, R D; Singh, U K; Mohan, LStaphylococcus aureus is a major pathogen for pyoderma in India. Phage pattern of bacteria gives valuable information in epidemiological studies of infection. Two hundred and two strains of Staphylococcus aureus isolated from pyoderma cases at Gorakhpur, were phage grouped and phage typed. It was found that 43.1 percent strains were not typable. Most common group was mixed phage group (23.8 percent) followed by phage group III (12.4 percent). Predominant phage types in mixed phage group was 84/81/85 and in phage group III was 84/85.Item Chorea mollis with carditis.(1977-05-16) Shah, D R; Bhatnagar, H N; Arora, S KItem A comparative study of common modes of tobacco use on pulse, blood pressure, electrocardiogram and blood coaguability in patients with coronary artery disease.(1977-06-01) Bordia, A; Purbiya, S L; Khabya, B L; Arora, S K; Hatimi, I H; Singh, S VItem A comparative study on effect of inhaled beclomethasone dipropionate and sodium cromoglycate on pulmonary functions in bronchial asthma.(1991-05-01) Narang, N K; Arora, S K; Chiplunkar, MItem The effect of essential oil (active principle) of Asafoetida on alimentary lipemia.(1975-05-01) Bordia, A; Arora, S KItem Effect of essential oil from onion on alimentary lipemia.(1974-01-01) Bordia, A; Bansal, H C; Khabiyaa, B L; Arora, S K; Singh, S VItem Effect of temperature on Leishmania mexicana amazonensis induced lesions in hamsters.(1987-07-01) Sehgal, S; Arora, S KItem Effect of the essential oil (active principal) of garlic on serum cholesterol, plasma fibrinogen, whole blood coagulation time and fibrinolytic activity in alimentary lipaemia.(1974-03-01) Bordia, A; Bansal, H C; Arora, S K; Rathore, A S; Ranawat, R V; Singh, S VItem Exhange transfusion in hepatic coma.(1975-05-01) Bhatnagar, H N; Shah, D R; Arora, S K; Bordia, AItem First site of lesion in leprosy cases.(1989-04-01) Arora, S K; Mukhija, R D; Narain, BItem High frequency of loss of allelic integrity at Wilms' tumor suppressor gene-1 locus in advanced breast tumors associated with aggressiveness of the tumor.(2009-10) Gupta, S; Joshi, K; Wig, J D; Arora, S KBackground: The product of Wilms' tumor suppressor gene (WT1), a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF) and transforming growth factor (TGF) systems, both of which are implicated in breast tumorigenesis and are known to facilitate angiogenesis. In the present study, WT1 allelic integrity was examined by Loss of Heterozygosity (LOH) studies in infiltrating breast carcinoma (n=60), ductal carcinoma in situ (DCIS) (n=10) and benign breast disease (n=5) patients, to determine its possible association with tumor progression. Methods: LOH at the WT1 locus (11p13) as determined by PCR-RFLP for Hinf1 restriction site and was subsequently examined for its association with intratumoral expression of various growth factors i.e. TGF-β1, IGF-II, IGF-1R and angiogenesis (VEGF and Intratumoral micro-vessel density) in breast carcinoma. Results: Six of 22 (27.2%) genetically heterozygous of infiltrating breast carcinoma and 1 of 4 DCIS cases showed loss of one allele at WT1 locus. Histologically, the tumors with LOH at WT1 were Intraductal carcinoma (IDC) and were of grade II and III. There was no correlation in the appearance of LOH at WT1 locus with age, tumor stage, menopausal status, chemotherapy status and lymph node metastasis. The expression of factor IGF-II and its receptor, IGF-1R was significantly higher in carcinoma having LOH at WT1 locus. A positive correlation was observed between the TGF-β1, VEGF expression and IMD scores in infiltrating carcinoma. Conclusions: The current study indicates that the high frequency of loss of allelic integrity at Wilms' tumor suppressor gene-1 locus in high-graded breast tumors is associated with aggressiveness of the tumor.Item Hypoglycaemic--hemiplegia.(1994-06-01) Gupta, A K; Dave, M; Arora, S K; Bhardwaja, BItem Immuno-stimulatory effect of levamisole in borderline leprosy cases.(1985-01-01) Arora, S K; Singh, G; Sen, P CEleven cases of borderline-borderline leprosy were subjected to levamisole therapy for 3 months. Levamisole was given 150 mg/day on three consecutive days every fortnight along with dapsone (DDS). Immuno-stimulation was assessed by lepromin test using Lepromin-A supplied by W.H.O. containing 4.0 X 10(7) bacilli per milli litre. It was found that there was statistically significant change in lepromin reaction after levamisole therapy.Item In vitro effect of soybean (Glycine max L. Merr)lectin on lipid peroxidation in pyridoxine deficient albino rats.(1987-11-01) Bansal, A K; Mehta, J; Mehta, M; Kumar, R; Arora, S K; Soni, G
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