About IMSEAR
Index Medicus for South-East Asia Region (IMSEAR) is an archive of selected publications in health sciences in the WHO South-East Asia Region. Materials in IMSEAR include formally published health science journals, health reports and documents.
Items in IMSEAR are organized under categories, sub-categories and collections reflecting type of materials, countries and journal titles. In addition to metadata of each item, original full text documents or links to original documents are provided whenever available, under Open Archives Initiative (OAI) framework. Items in IMSEAR can also be harvested through OAI-PMH at the base URL: https://imsear.searo.who.int/server/oai/request.
You are welcome to register yourself at the IMSEAR and subscribe to our collections to receive email alerts whenever new items are added to the collection. If you would like to include your publications in IMSEAR, please contact searolibrary@who.int at the WHO Regional Office for South-East Asia.
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Recent Submissions
Assessing the Effects of Hypertension on Body Composition and Biochemical Markers
(Society for Scientific Research, 2024-12) Agrahari, P; Jain, A; Jain, J; Mishra, A; Kumar, A; Tiwari, S.
SSR Institute of International Journal of Life Sciences ISSN (O): 2581-8740 | ISSN (P): 2581-8732 Agrahari et al., 2024 DOI: 10.21276/SSR-IIJLS.2024.10.6.9 Copyright © 2024| SSR-IIJLS by Society for Scientific Research under a CC BY-NC 4.0 International License Volume 10 | Issue 06 | Page 6410 Assessing the Effects of Hypertension on Body Composition and Biochemical Markers Priyanka Agrahari1, Ashutosh Jain2, Jaya Jain3, Anand Mishra4, Amit Kumar5, Sanchit Tiwari6* 1Ph.D. Research Scholar, Department of Biochemistry, Index Medical College Hospital and Research Centre, Indore, India 2Assistant Professor, Department of Physiology, Index Medical College Hospital and Research Centre, Indore, India 3Associate Professor, Department of Biochemistry, Index Medical College Hospital and Research Centre, Indore, India 4Professor, Department of Biochemistry, MVASMC, Ghazipur, India 5Associate Professor, Department of Biochemistry, MVASMC, Ghazipur, India 6Assistant Professor, Department of Biochemistry, MVASMC, Ghazipur, India *Address for Correspondence: Dr. Sanchit Tiwari, Assistant Professor, Department of Biochemistry, MVASMC, Ghazipur, India E-mail: sanc13sep@gmail.com & ORCID ID: https://orcid.org/0000-0002-9659-3757 Received: 15 July 2024/ Revised: 17 Aug 2024/ Accepted: 14 Oct 2024 ABSTRACT Background: Hypertension is a widespread health concern globally, contributing significantly to morbidity and mortality. In India, it affects a considerable portion of the population, with lifestyle factors contributing to its rise. This study aims to analyze the relationship between various biochemical parameters and gender-specific differences in hypertensive individuals compared to a control group. Methods: A case-control observational study was conducted with 240 participants aged 30-60 years, consisting of 120 hypertensive patients and 120 controls, recruited from the outpatient department of Index Medical College, Hospital and Research centre, Indore. Anthropometric measurements, blood pressure readings, and biochemical analyses were performed. Statistical analyses were conducted using Student's t-test and Pearson’s correlation. Results: Significant differences were observed in anthropometric parameters, with hypertensive subjects exhibiting increased height, weight, BMI, and waist-to-hip ratio (WHR) (p<0.001). Biochemically, hypertensive individuals had elevated fasting blood sugar, HbA1c, triglycerides, low-density lipoprotein (LDL), and uric acid, along with decreased high-density lipoprotein (HDL) levels (p<0.001). Gender-wise analysis revealed higher uric acid levels in females and lower HDL compared to males. Positive correlations were established between systolic/diastolic blood pressure and BMI, creatinine, and uric acid levels. Conclusion: The study highlights significant alterations in anthropometric and biochemical parameters in hypertensive subjects compared to controls. Elevated BMI, uric acid, and creatinine levels were associated with hypertension, emphasizing the need for targeted interventions. The findings support the importance of regular monitoring of cardiovascular and renal health in hypertensive patients, considering gender-specific differences in risk profiles.
Vitamin B12 Deficiency and Hyperhomocysteinemia in Pre-Eclampsia: Assessing Biochemical Markers for Disease Prediction and Therapeutic Potential
(Society for Scientific Research, 2024-12) Kumar, A; Jain, J.
Background: PE is a pregnancy-specific disorder with the onset of hypertension and proteinuria beyond 20 weeks of gestation. Several lines of evidence indicate that vitamin B12 deficiency and hyperhomocysteinemia (Hcy) may play a role in endothelial dysfunction in PE. Finding these markers could lead to earlier diagnoses and prevention in high-risk populations. Methods: We carried out a cross-sectional study of 120 pregnant women (60 with PE and 60 with normotensive controls). Vitamin B12 levels in serum and plasma homocysteine levels were measured. Independent t-tests were made to compare these markers, and correlations between these markers and PE severity were analyzed. Results: The PE group had significantly lower (p<0.01) Vitamin B12 and significantly higher (p<0.01) homocysteine. The existence of positive correlations between homocysteine and blood pressure supports a possible role of Hcy in endothelial dysfunction. Conclusion: PE risks rise in conjunction with Vitamin B12 deficiency and elevated homocysteine, and therefore these biomarkers could prove helpful in predicting PE early. The purpose of these assessments may be to improve outcomes by integrating them into prenatal care.
Copeptin Levels in Coronary Artery Disease: A Comparative Analysis
(Society for Scientific Research, 2024-12) Samal, P; Sahu, PK; Das, DR; Joshi, PR; Nayak, S; Sarangi, P; Panda, P; Panigrahi, K; Mohapatra, D.
Background: Coronary artery disease (CAD) is the most common heart disease, ranging from asymptomatic atherosclerosis and stable angina to acute coronary syndromes. Copeptin, a 39-amino acid glycoprotein, being stable, is easily measurable in peripheral blood and has potential as a biomarker in cardiac diseases like heart failure and acute coronary syndromes The objective of this study was to evaluate the differences in copeptin levels between CAD patients and healthy controls and to assess the potential of copeptin as a biomarker for CAD. Methods: This observational case-control study, approved by the Institutional Ethics Committee, was carried out at S.C.B Medical College and Hospital, Cuttack, from 2020 to 2022. The study involved 80 CAD patients along with an equal number of age- and sex-matched controls. Exclusion criteria included acute or chronic kidney disease, traumatic heart disease, head injury, severe morbidity, or refusal to participate. Copeptin levels were measured by Enzyme-linked immunoassay (ELISA). Results: Severe CAD was observed in 56.25% of the cases, with 30% having moderate CAD. CAD patients exhibited significantly higher copeptin levels compared to controls (p<0.0001). ROC curve analysis identified a cut-off value of 0.98, with a sensitivity of 83.8% and a specificity of 76.2%. Conclusion: CAD patients exhibited higher copeptin levels compared to healthy controls, suggesting that copeptin can serve as a biomarker for CAD.
Management of Pediatric Blunt Trauma Abdomen in a Tertiary Care Center: A Retrospective Record Based Study
(Society for Scientific Research, 2024-12) Ramila, R; Sudarshan, N.
Background: Trauma is one of the leading causes of death and disability worldwide. 25% of pediatric patients with major trauma usually because of abdominal injury. Less aggressive treatment and selective operative interventions have become the new standard of care. Most of the cases do not require surgical intervention and can be managed conservatively. Methods: The retrospective cross-sectional study encompassed patients under 18 years with blunt abdominal trauma, eliminating isolated organ injuries, penetrating trauma, sexual assault, and drowning incidents. Demographic data, injury classifications, management strategies, and outcomes were examined, with conservative or surgical approaches determined by clinical factors and imaging results. Results: With a median age of 9.75 years, 75% of the 144 pediatric cases of blunt abdominal trauma were male. The predominant injury mechanisms were two-wheeler road traffic accidents (57.2%) and bicycle handle injuries (13.1%). Of these, 81.25% were treated conservatively. The most damaged organs were the spleen (29.6%) and liver (42.7%). 18.75% needed surgery for hollow viscus perforations and solid organ damage. Conclusion: This study shows that conservative treatment works for stable pediatric blunt abdominal trauma patients of any grade. FAST and CT scans help triage and manage injuries, but physiological reaction, not injury grade, should drive therapy. Pediatric surgeons and interventional radiologists ensure fewer significant interventions.
Evaluation of Etiopathology and Management of Primary and Secondary Amenorrhea in Adolescent and Young Women in North Indian Population
(Society for Scientific Research, 2024-12) Deo, S; Singh, S; Kumari, P; Agarwal, M; Ali, W; Nigam, N.
Background: Amenorrhea, the absence of menstruation, is categorized into primary (before menarche) and secondary (after menarche) forms, with significant implications for female reproductive health. Methods: This observational study conducted at the Department of Obstetrics and Gynaecology, King George’s Medical University, assessed the etiological factors and management of amenorrhea in adolescent and young women aged 11-24 years from January 2020 to January 2021. Results: Out of 73 participants, 42.46% were diagnosed with primary amenorrhea, while 57.54% had secondary amenorrhea. Mullerian anomalies were identified as the leading cause of primary amenorrhea, accounting for 83.8% of cases. Other causes included imperforate hymen (9.67%), constitutional delay (9.27%), androgen insensitivity syndrome (3.23%), and Turner variant (3.23%). In contrast, polycystic ovary syndrome (PCOS) emerged as the most common cause of secondary amenorrhea, observed in 80.95% of cases, followed by hyperprolactinemia (7.14%), hypothyroidism (7.14%), premature ovarian failure (2.38%), and Asherman syndrome (2.38%). Management strategies were tailored to the underlying etiology, with surgical interventions such as vaginoplasty (48.39%), septum excision (3.23%), and cruciate incision (9.68%) being the primary treatments for structural causes of primary amenorrhea. For secondary amenorrhea, out of 42 cases 34 PCOS and 1 premature ovarian failure patient i.e. 83.34% were particularly treated by lifestyle modification and cyclical E+P therapy, 1(2.38%) by Hysteroscopic adhesiolysis for Ashman’s Syndrome, 3(7.14) by cabergoline treatment for hyperprolactinemia and 3 (7.14%) hypothyroidism by thyroxin treatment. Conclusion: The study underscores the importance of early diagnosis and individualized treatment to enhance reproductive health outcomes in affected women. The findings also emphasize the need for further research to evaluate long-term outcomes and refine management protocols for both primary and secondary amenorrhea, ultimately aiming to improve patient care and fertility prospects.