The role of liver in metabolism: an updated review with physiological emphasis

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dc.contributor.authorAlamri, Zaenah Zuhairen_US
dc.date.accessioned2020-04-23T07:52:34Z
dc.date.available2020-04-23T07:52:34Z
dc.date.issued2018-11
dc.description.abstractLiver plays an essential role in metabolism and has an important role in preserving and regulating the levels of lipid, glucose in the body as well as energy metabolism. Among the important functions performed by the liver is maintaining of blood glucose levels under different conditions through group of processes included; glycolysis, glycogenesis, glycogenolysis, gluconeogenesis. The absorbed free fatty acids and those derived from the adipose tissue reach the liver and are utilized for energy, membrane synthesis, or stored as triglyceride. In addition, the liver has a crucial role in keeping homeostasis of body level of cholesterol. Regarding protein metabolism, urea cycle occurs in the liver through the action of urea cycle enzymes to produce urea in order to get rid of the toxic ammonia. In the liver, cholesterol is utilized for bile acids synthesis through a complicated process. These bile acids are considered essential in order to absorb and transport of lipid-soluble vitamins dietary and fat in the diet as well as clearance of drugs, toxic substances and xenobiotics. Adding to these hepatic functions is hepatic detoxification where liver metabolizes a various type of drugs to make soluble execretable compounds. In conclusion, the liver has so important metabolic functions which if impaired will resulted in many liver diseases and might progress to more dangerous conditions such as liver fibrosis or cirrhosis.en_US
dc.identifier.affiliationsDepartment of Biology, Faculty of Science, Jeddah University, Saudi Arabiaen_US
dc.identifier.citationAlamri Zaenah Zuhair. The role of liver in metabolism: an updated review with physiological emphasis. International Journal of Basic & Clinical Pharmacology. 2018 Nov; 7(11): 2271-2276en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199921
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20184211en_US
dc.subjectBile acidsen_US
dc.subjectCircadianen_US
dc.subjectCarbohydratesen_US
dc.subjectDrugsen_US
dc.subjectLiveren_US
dc.subjectLipidsen_US
dc.subjectMetabolismen_US
dc.subjectProteinsen_US
dc.subjectPhysiologyen_US
dc.titleThe role of liver in metabolism: an updated review with physiological emphasisen_US
dc.typeJournal Articleen_US
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