Inverse correlation between macrophage-colony stimulating factor, cholesterol and high density lipoprotein cholesterol in Kawasaki disease.

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dc.contributor.authorShikishima, Yen_US
dc.contributor.authorKawano, Yen_US
dc.contributor.authorShirai, Hen_US
dc.contributor.authorMatsuura, Nen_US
dc.contributor.authorNoma, Ten_US
dc.date.accessioned2009-05-27T17:12:43Z
dc.date.available2009-05-27T17:12:43Z
dc.date.issued2001-06-09en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractKawasaki disease (KD) is a childhood-onset vascular disease. We assessed the concentrations of macrophage-colony stimulating factor (M-CSF) and those of lipids in sera from patients with KD. The M-CSF concentration in patients with acute-phase KD was 2,914+/-159 U/ml, significantly higher than that in control subjects with Infectious diseases (1,241+/-96 U/ml). The elevated levels of this cytokine in the acute phase fell to 1,319+/-138 U/ml in the convalescent phase. Total and high-density lipoprotein cholesterol concentrations in acute phase KD (113.8+/-8.4 and 21.5+/-2.3 mg/dl, respectively) were lower than in the infectious disease controls (195.8+/-7.0 and 62.5+/-1.8 mg/dl). The elevation of M-CSF correlated with the decrease of total and high-density lipoprotein cholesterol. Overproduction of macrophage-colony stimulating factor activates macrophages and monocytes and may disturb the lipid metabolism. Both effects could contribute to vasculitis in KD.en_US
dc.description.affiliationDepartment of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan.en_US
dc.identifier.citationShikishima Y, Kawano Y, Shirai H, Matsuura N, Noma T. Inverse correlation between macrophage-colony stimulating factor, cholesterol and high density lipoprotein cholesterol in Kawasaki disease. Asian Pacific Journal of Allergy and Immunology. 2001 Jun; 19(2): 85-91en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36695
dc.language.isoengen_US
dc.subject.meshChild Welfareen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCholesterol --blooden_US
dc.subject.meshCholesterol, HDL --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins, Intravenous --therapeutic useen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant Welfareen_US
dc.subject.meshJapan --epidemiologyen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshMacrophage Colony-Stimulating Factor --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMonocytes --cytologyen_US
dc.subject.meshMucocutaneous Lymph Node Syndrome --blooden_US
dc.subject.meshStatistics as Topicen_US
dc.titleInverse correlation between macrophage-colony stimulating factor, cholesterol and high density lipoprotein cholesterol in Kawasaki disease.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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