Initial drug resistance pattern among Pulmonary Tuberculosis patients.

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dc.contributor.authorGupta, Harshita
dc.contributor.authorKant, Surya
dc.contributor.authorJain, Amita
dc.contributor.authorNatu, S M
dc.contributor.authorAhluwalia, Savita
dc.date.accessioned2015-07-17T10:23:05Z
dc.date.available2015-07-17T10:23:05Z
dc.date.issued2013-07
dc.description.abstractBackground: Drug resistant tuberculosis (DRTB) is an emerging problem that adversely affects treatment outcomes and public health in the developing world. Objective: To determine the initial drug resistance pattern among pulmonary tuberculosis patients registered under the Revised National Tuberculosis Control Programme. Study Design: A cross-sectional study design. Setting: Two urban Directly Observed Treatment Supervised (DOTS) centres in Lucknow District of Uttar Pradesh. Methods: The present study consisted of newly diagnosed sputum smear-positive for acid-fast bacilli (AFB) cases at the time of registration under the tuberculosis control programme. All sputum smear positive cases were subjected to culture and drug-susceptibility testing by 1% proportion method on Lowenstein-Jensen (LJ) medium. Results: A total of 185 newly diagnosed sputum smear positive for AFB in pulmonary tuberculosis patients were subjected to culture and drug sensitivity test. Among 185 isolates, 170 (91.4%) isolates were culture positive. Of these 170 isolates, 169 (99.4%) were M. tuberculosis and one (0.5%) was Mycobacterium other than tuberculosis (MOTT). Out of 99.4% M. tuberculosis positive isolates, 21.3% were resistant to at least one drug. Resistance pattern of 21.3% strains of M. tuberculosis showing resistance to single, double, triple, and quadruple drugs were 5.9%, 10.7%, 2.4% and 2.4% respectively. Multi-drug resistance (MDR) was observed in 4.7% isolates. Conclusion: The present study highlights the high rate of drug resistance pattern among the new sputum smear positive pulmonary tuberculosis patients and also high MDR tuberculosis. Routine surveillance of drug resistance profile of patients provides useful information for adopting new strategies of effective treatment within National Tuberculosis Control Programmes in order to combat the threat of MDR-TB in the general population.en_US
dc.identifier.citationGupta Harshita, Kant Surya, Jain Amita, Natu S M, Ahluwalia Savita. Initial drug resistance pattern among Pulmonary Tuberculosis patients. Indian Journal of Tuberculosis. 2013 Jul; 60(3): 154-161.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159958
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ibr/t13/i3/ibrt13i3p154.pdfen_US
dc.subjectTuberculosisen_US
dc.subjectInitial drug resistanceen_US
dc.subjectMulti-drug resistanceen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntitubercular Agents --administration & dosage
dc.subject.meshCross-Sectional Studies
dc.subject.meshDrug Resistance, Bacterial
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshIndia --epidemiology
dc.subject.meshMale
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMycobacterium tuberculosis --drug effects
dc.subject.meshMycobacterium tuberculosis --isolation & purification
dc.subject.meshSputum --microbiology
dc.subject.meshTreatment Outcome
dc.subject.meshTuberculosis, Multidrug-Resistant --diagnosis
dc.subject.meshTuberculosis, Multidrug-Resistant --drug therapy
dc.subject.meshTuberculosis, Multidrug-Resistant --epidemiology
dc.subject.meshTuberculosis, Pulmonary --diagnosis
dc.subject.meshTuberculosis, Pulmonary --drug therapy
dc.subject.meshTuberculosis, Pulmonary --epidemiology
dc.titleInitial drug resistance pattern among Pulmonary Tuberculosis patients.en_US
dc.typeArticleen_US
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