Antimicrobial activities of four Tunisian Chrysanthemum species.

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dc.contributor.authorSassi, Ahlem Benen_US
dc.contributor.authorHarzallah-Skhiri, Fethiaen_US
dc.contributor.authorBourgougnon, Nathalieen_US
dc.contributor.authorAouni, Mahjouben_US
dc.date.accessioned2008-02-12en_US
dc.date.accessioned2009-05-27T07:04:09Z
dc.date.available2008-02-12en_US
dc.date.available2009-05-27T07:04:09Z
dc.date.issued2008-02-12en_US
dc.description.abstractBACKGROUND & OBJECTIVE: Tunisian Chrysanthemum species are known to have medicinal activity and some of the species are used in traditional medicine. We have earlier shown the use of C. trifurcatum flowerheads in Tunisian traditional medicine to treat constipation. In the present study we investigated the anti microbiol activity of four Tunision Chrysanthemum species. METHODS: Different parts (flowers, leaves, stems, roots, leaves and flowers and leaves and stems) of four Tunisian Chrysanthemum species, were extracted with solvents of increasing polarity to obtain aqueous and organic extracts. These extracts were tested in vitro for their antimicrobial activity against 14 bacteria and four yeasts, using agar diffusion and microdilution methods. Activity was evaluated by measuring the zones of inhibition against the tested organisms and minimum inhibitory concentrations (MIC) were determined from the lowest concentrations of extracts to inhibit the growth of microorganisms. Cytotoxity and antiviral activities against Herpes simplex virus type 1 (HSV-1), were evaluated using the neutral red incorporation method. RESULTS: Extracts of the 4 Chrysanthemum species showed some degree of activity against one or more of the microbial strains with MIC ranging from 0.625 to 1.25 mg/ml. Most of the extracts were well tolerated by Vero cells with CC(50) > 500 microg/ml. The petroleum ether extract of C. trifurcatum stems and leaves protected infected cells with EC(50) of 100 microg/ml. INTERPRETATION & CONCLUSION: Our findings showed that some Chrysanthemum extracts exhibited antimicrobial and/or anti-HSV-1 activities. Further studies aimed to the isolation and identification of active substances from the extracts which exhibited interest activities, need to be done.en_US
dc.description.affiliationLaboratoire des Maladies Transmissibles et Substances Biologiquement Actives, Faculté de Pharmacie, Monastir, France. ahlem_ben_sassi@yahoo.fren_US
dc.identifier.citationSassi AB, Harzallah-Skhiri F, Bourgougnon N, Aouni M. Antimicrobial activities of four Tunisian Chrysanthemum species. Indian Journal of Medical Research. 2008 Feb; 127(2): 183-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19164
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Infective Agents --pharmacologyen_US
dc.subject.meshCercopithecus aethiopsen_US
dc.subject.meshChemistry, Pharmaceutical --methodsen_US
dc.subject.meshChrysanthemum --metabolismen_US
dc.subject.meshFlowers --metabolismen_US
dc.subject.meshMedicine, Traditionalen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshPhytotherapy --methodsen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlant Roots --metabolismen_US
dc.subject.meshPlant Stems --metabolismen_US
dc.subject.meshTunisiaen_US
dc.subject.meshVero Cellsen_US
dc.titleAntimicrobial activities of four Tunisian Chrysanthemum species.en_US
dc.typeJournal Articleen_US
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