Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats.

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dc.contributor.authorRamanathan, Men_US
dc.contributor.authorSivakumar, Sen_US
dc.contributor.authorAnandvijayakumar, P Ren_US
dc.contributor.authorSaravanababu, Cen_US
dc.contributor.authorPandian, P Rathinavelen_US
dc.date.accessioned2009-05-28T12:00:54Z
dc.date.available2009-05-28T12:00:54Z
dc.date.issued2007-05-16en_US
dc.description.abstractThe effect of chloroform: methanolic (80:20) extract of C. asiatica (CA; 100 and 200 mg/kg), was evaluated on the course of free radical generation and excitotoxicity in monosodiumglutamate (MSG) treated female Sprague Dawley rats. The extract showed significant improvement in catalase, super oxide desmutase and lipid peroxides levels in hippocampus and striatum regions. Glutathione level was not altered with CA treatment. Similar observation was made with dextromethorphan. The general behavior, locomotor activity and CAl a region of the hippocampus was significantly protected by CA indicating neuroprotective effect of CA in MSG induced excitotoxic condition. Hence it can be concluded that CA protected MSG induced neurodegeneration attributed to its antioxidant and behavioural properties. This activity of CA can be explored in epilepsy, stroke and other degenerative conditions in which the role of glutamate is known to play vital role in the pathogenesis.en_US
dc.description.affiliationNeuropharmacology Laboratory, Department of Pharmacology, J. S. S. College of Pharmacy, Ootacamund, 643 001, India. muthiahramanathanin@yahoo.co.inen_US
dc.identifier.citationRamanathan M, Sivakumar S, Anandvijayakumar PR, Saravanababu C, Pandian PR. Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats. Indian Journal of Experimental Biology. 2007 May; 45(5): 425-31en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57507
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5525/1/IJEB%2045%285%29%20425-431.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animal --drug effectsen_US
dc.subject.meshCatalase --analysisen_US
dc.subject.meshCentella --chemistryen_US
dc.subject.meshCorpus Striatum --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione --analysisen_US
dc.subject.meshHippocampus --chemistryen_US
dc.subject.meshNeurodegenerative Diseases --chemically induceden_US
dc.subject.meshNeuroprotective Agents --therapeutic useen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSodium Glutamateen_US
dc.subject.meshSuperoxide Dismutase --analysisen_US
dc.subject.meshThiobarbituric Acid Reactive Substances --analysisen_US
dc.titleNeuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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