Human leukocyte antigen alleles, genotypes and haplotypes frequencies in renal transplant donors and recipients from West Central India.

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dc.contributor.authorPatel, Jaina S
dc.contributor.authorPatel, Manisha M
dc.contributor.authorKoringa, Prakash G
dc.contributor.authorShah, Tejas M
dc.contributor.authorPatel, Amrutlal K
dc.contributor.authorTripathi, Ajai K
dc.contributor.authorMathew, Anila
dc.contributor.authorRajapurkar, Mohan M
dc.contributor.authorJoshi, Chaitanya G
dc.date.accessioned2013-11-20T09:37:37Z
dc.date.available2013-11-20T09:37:37Z
dc.date.issued2013-04
dc.description.abstractBACKGROUND: Human leukocyte antigen (HLA) is comprised of a highly polymorphic set of genes which determines the histocompatibility of organ transplantation. The present study was undertaken to identify HLA class I and class II allele, genotype and haplotype frequencies in renal transplant recipients and donors from West Central India. MATERIALS AND METHODS: HLA typing was carried out using Polymerase Chain Reaction-Sequence Specific Primer in 552 live related and unrelated renal transplant recipients and donors. RESULTS: The most frequent HLA class I and class II alleles and their frequencies in recipients were HLA-AFNx0101 (0.1685) and AFNx0102 (0.1649), HLA-BFNx0135 (0.1322), and HLA-DR beta 1 (DRB 1)FNx0115 (0.2192), whereas in donors, these were HLA-AFNx0102 (0.1848) and AFNx0101 (0.1667), HLA-BFNx0135 (0.1359), and HLA-DRB1FNx0115 (0.2409). The two-locus haplotype statistical analysis revealed HLA-AFNx0102-B61 as the most common haplotype with the frequency of 0.0487 and 0.0510 in recipients and donors, respectively. Further, among the three locus haplotypes HLA-AFNx0133-BFNx0144-DRB1FNx0107 and HLA-AFNx0102-BFNx0161-DRB1FNx0115 were the most common haplotypes with frequencies 0.0362 and 0.0326, respectively in recipients and 0.0236 and 0.0323, respectively in donors. Genotype frequency revealed a high prevalence of genotype HLA-AFNx0102/AFNx0124 in recipients (0.058) compared to donors (0.0109) whereas low prevalence of HLA-AFNx0101/AFNx0102 in recipients (0.0435) than in donors (0.0797). The phylogenetic and principal component analysis of HLA allele and haplotype frequency distribution revealed genetic similarities of various ethnic groups. Further, case control analysis provides preliminary evidence of association of HLA-A genotype (P < 0.05) with renal failure. CONCLUSION: This study will be helpful in suitable donor search besides providing valuable information for population genetics and HLA disease association analysis.en_US
dc.identifier.citationPatel Jaina S, Patel Manisha M, Koringa Prakash G, Shah Tejas M, Patel Amrutlal K, Tripathi Ajai K, Mathew Anila, Rajapurkar Mohan M, Joshi Chaitanya G. Human leukocyte antigen alleles, genotypes and haplotypes frequencies in renal transplant donors and recipients from West Central India. Indian Journal of Human Genetics. 2013 Apr; 19(2): 219-232.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149433
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758731/?report=classicen_US
dc.subjectAlleleen_US
dc.subjectgenotypeen_US
dc.subjecthaplotypeen_US
dc.subjecthuman leukocyte antigens frequenciesen_US
dc.subjectpolymorphismen_US
dc.subjectrenal transplanten_US
dc.subject.meshAlleles
dc.subject.meshEthnic Groups --genetics
dc.subject.meshGenotype
dc.subject.meshHLA Antigens --classification
dc.subject.meshHLA Antigens --genetics
dc.subject.meshHaplotypes
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshKidney Transplantation --immunology
dc.subject.meshPolymorphism, Genetic
dc.titleHuman leukocyte antigen alleles, genotypes and haplotypes frequencies in renal transplant donors and recipients from West Central India.en_US
dc.typeArticleen_US
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