Conformal radiotherapy plans for palliative bone metastasis - comparison of dosimetric parameters

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dc.contributor.authorGupta, Nen_US
dc.contributor.authorKumar, Pen_US
dc.contributor.authorKumar, Pen_US
dc.contributor.authorNavitha, Sen_US
dc.contributor.authorMehta, Aen_US
dc.contributor.authorChauhan, Aen_US
dc.date.accessioned2020-09-24T07:54:37Z
dc.date.available2020-09-24T07:54:37Z
dc.date.issued2020-06
dc.description.abstractBackground:Palliative radiotherapy offers significant relief in the huge physical distress of patients with bony metastasis. The enormous potential of conformal techniques has not been tested in palliative settings. However,the increasing life span of patients with metastatic disease demands to optimize the radiotherapy techniques to provide maximal durable symptomatic relief. Despitean increase in the utilization of the 3DCRT technique for palliative bony metastasis, the optimal beam arrangement remains unknown. Materials and Methods:Ten patients of vertebral bony metastasis were retrospectively selected and four virtual 3DCRT plans were generated for each patient. The field approaches were a single field, two fields, three fields and five field approaches. For PTV, D90, D50, Dmean, Conformity index (CI) were evaluated.Dmean was evaluated for the esophagus, bowel, kidneys, and combined lungs. Dose-volume histograms were computed for the various treatment plans and compared. Statistical analysis was done by ANOVA test. Results:A total of forty radiotherapy plans were generated. PTV parameters were significantly better with two field plans over one field plans in terms of D90 (p= 0.002), D50 (p= 0.02), Dmean(p=0.0009). Dmeanwassignificantly better with three field approach compared to two field approach (p=0.0006). The Dmeanwas significantly increased for organs at risk in two fields and three field plans.Five field approach did not showan advantage in terms of dosimetry of PTV but there was a significant rise in the dose to Organs at risk (OAR’s). Conclusion:The three field plans showed better dose distribution to the PTV with an acceptable increase in the dose to OAR’s.en_US
dc.identifier.affiliationsDr. Naina Gupta Junior Resident, Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr. Pavan Kumar Assistant Professor, Department of Radiation oncology, Shri Ram Murti Smarak institute of medical sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr. Piyush Kumar Professor and Head, Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsMrs. S. Navitha Assistant Professor Cum Medical Physicist, Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr. Ankita Mehta Junior Resident, Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr. Arvind Chauhan Professor, Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.citationGupta N, Kumar P, Kumar P, Navitha S, Mehta A, Chauhan A. Conformal radiotherapy plans for palliative bone metastasis - comparison of dosimetric parameters. International Journal of Medical Research & Review. 2020 Jun; 8(3): 228-233en_US
dc.identifier.issn2320-8686
dc.identifier.issn2321-127X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205351
dc.languageenen_US
dc.publisherSiddharth Health Research and Social Welfare Societyen_US
dc.relation.issuenumber3en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.17511/ijmrr.2020.i03.02en_US
dc.subjectDosimetric parametersen_US
dc.subjectBone metastasisen_US
dc.subjectConformal radiotherapy plansen_US
dc.titleConformal radiotherapy plans for palliative bone metastasis - comparison of dosimetric parametersen_US
dc.typeJournal Articleen_US
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