Humoral immunity response in malignancies with special reference to the effect of radiotherapy.

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dc.contributor.authorBanerjee, Sen_US
dc.contributor.authorMullick, S Nen_US
dc.contributor.authorSarkar, S Ken_US
dc.contributor.authorBasu, Ren_US
dc.contributor.authorSanyal, Sen_US
dc.date.accessioned1994-10-01en_US
dc.date.accessioned2009-05-31T12:13:58Z
dc.date.available1994-10-01en_US
dc.date.available2009-05-31T12:13:58Z
dc.date.issued1994-10-01en_US
dc.description.abstractIn view of the variability in the findings recorded by different authors in the level of immunoglobulins in patients suffering from malignancies, a study on 34 cases of six types of malignancies treated with radiotherapy (telecobalt and telecesium) was carried out to record the humoral response and also to compare the response during radiotherapy and after radiotherapy in these cases. Serum of 20 age-matched normal volunteers served as normal control. The study recorded that the pretherapy levels of IgA and IgG were raised in most of the cases; but the IgM was decreased than that of the control level. This is probably due to the fact that the selective clones of cells producing different types of immunoglobulins are responding to the malignancies in different ways. The midtherapy level of all immunoglobulins showed the value lower than the pretherapy level, but recovery was observed in the post-therapy period with all immunoglobulins in all the cases irrespective of the histological types of malignancies. It was also apparent from this study that the post-therapy gain in the level of immunoglobulins over midtherapy level was more pronounced in cases having telecobalt therapy. Assessment of humoral response in 25 patients suffering from squamous cell carcinoma of different grades revealed that the midtherapy fall and subsequent post-therapy gain had no definite correlation with grading.en_US
dc.description.affiliationDepartment of Pathology, Medical College, Calcutta.en_US
dc.identifier.citationBanerjee S, Mullick SN, Sarkar SK, Basu R, Sanyal S. Humoral immunity response in malignancies with special reference to the effect of radiotherapy. Journal of the Indian Medical Association. 1994 Oct; 92(10): 323-5, 330en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/100887
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAdulten_US
dc.subject.meshAntibody Formationen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins --blooden_US
dc.subject.meshMatched-Pair Analysisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasms --blooden_US
dc.subject.meshRetrospective Studiesen_US
dc.titleHumoral immunity response in malignancies with special reference to the effect of radiotherapy.en_US
dc.typeJournal Articleen_US
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