Correlation of clinico-pathologic and radiologic parameters of response to neoadjuvant chemotherapy in breast cancer.

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dc.contributor.authorMukherjee, P
dc.contributor.authorSharma, S
dc.contributor.authorSheikh, Z A
dc.contributor.authorVijaykumar, D K
dc.date.accessioned2014-12-29T10:09:27Z
dc.date.available2014-12-29T10:09:27Z
dc.date.issued2014-01
dc.description.abstractCONTEXT: As of today, there is no validated standard method to assess clinical response of breast cancer to neo- adjuvant chemotherapy (NACT). Some centers use clinical dimensions while others use radiological measurements to evaluate response according to RECIST criteria. AIMS: The aim was to correlate and compare the clinical, radiological, and pathological parameters for assessing the tumor response in patients of breast cancer receiving NACT. SETTINGS AND DESIGN: Single institution, prospective nonrandomized study conducted over a 2-year period. MATERIALS AND METHODS: Patients with diagnosed breast cancer were assessed for response to NACT prior to surgery using clinical and radiological techniques. This was correlated with pathological reponse which was assessed by measuring gross dimensions and Miller-Payne grading of response to chemotherapy. STATISTICAL ANALYSIS USED: Spearman’s rho nonparametric. RESULTS: Fifty two patients completed the evaluation (out of 313 cases of ca breast treated during the same period) with a median age of 52.5 years. We noted a 26.9% clinical complete response (CR) and 19.2% had pathological CR. Clinical evaluation had a sensitivity and specificity of 73.5% and 88.5% respectively compared to 14.2% and 100% respectively for radiological assessment. CONCLUSIONS: Clinical assessment of response to NACT shows a higher sensitivity compared to radiological assessment. However the overall low sensitivity and specificity rates of clinical assessment mandate a search for a better method of evaluation.en_US
dc.identifier.citationMukherjee P, Sharma S, Sheikh Z A, Vijaykumar D K. Correlation of clinico-pathologic and radiologic parameters of response to neoadjuvant chemotherapy in breast cancer. Indian Journal of Cancer. 2014 Jan-Mar; 51(1): 25-28..en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154278
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2014;volume=51;issue=1;spage=25;epage=29;aulast=Mukherjeeen_US
dc.subjectBreast Canceren_US
dc.subjectpathological criteriaen_US
dc.subjectprimary chemotherapyen_US
dc.subjectradiological assessmenten_US
dc.subjectRECIST criteriaen_US
dc.subjectresponse assessmenten_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic use
dc.subject.meshBreast Neoplasms --drug therapy
dc.subject.meshBreast Neoplasms --pathology
dc.subject.meshBreast Neoplasms --radiotherapy
dc.subject.meshCarcinoma, Ductal, Breast --drug therapy
dc.subject.meshCarcinoma, Ductal, Breast --pathology
dc.subject.meshCarcinoma, Ductal, Breast --radiotherapy
dc.subject.meshChemotherapy, Adjuvant
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshNeoadjuvant Therapy
dc.subject.meshNeoplasm Staging
dc.subject.meshPrognosis
dc.subject.meshProspective Studies
dc.subject.meshROC Curve
dc.subject.meshRemission Induction
dc.titleCorrelation of clinico-pathologic and radiologic parameters of response to neoadjuvant chemotherapy in breast cancer.en_US
dc.typeArticleen_US
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