Langerhans' cell histiocytosis: a clinicopathological study of 50 cases.

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dc.contributor.authorChhabra, Udita Den_US
dc.contributor.authorDesai, Saral Sen_US
dc.contributor.authorJambhekar, Nirmala Aen_US
dc.date.accessioned2004-07-22en_US
dc.date.accessioned2009-05-29T13:39:57Z
dc.date.available2004-07-22en_US
dc.date.available2009-05-29T13:39:57Z
dc.date.issued2004-07-22en_US
dc.description.abstractTo analyze the clinicopathologic features and outcome of patients with Langerhans cell histiocytosis (LCH). Fifty cases of LCH accrued over a 15-year period were analyzed and classified as having unifocal, multifocal, or multisystem disease. Events regarding progression, relapse, or death were noted. The 50 cases comprised of 34 men and 16 women. 92% of the patients were less than 15 years of age and 46% were less than 2 years. Involvement by LCH was unifocal in 22, multifocal in 8, and multisystem in 20. Bone was the commonest site (92%), followed by lymph node (30%). The histological features were relatively uniform regardless of the clinical severity, and consisted of Langerhans cells, eosinophils, histiocytes, plasma cells, giant cells and fibrosis. The treatment consisted of surgery, chemotherapy, and/or radiotherapy. Response to treatment was poor in patients with multisystem disease. The histology of LCH is very characteristic and patients with age less than 2 years are more likely to have increased risk or morbidity and mortality, due to widespread disease.en_US
dc.description.affiliationDepartment of Pathology, Tata Memorial Hospital, Mumbai.en_US
dc.identifier.citationChhabra UD, Desai SS, Jambhekar NA. Langerhans' cell histiocytosis: a clinicopathological study of 50 cases. Indian Journal of Pathology & Microbiology. 2004 Jul; 47(3): 370-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75891
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHistiocytosis, Langerhans-Cell --classificationen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSkull --radiographyen_US
dc.titleLangerhans' cell histiocytosis: a clinicopathological study of 50 cases.en_US
dc.typeJournal Articleen_US
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