The Effect of Ethanolic Seed Extract of Citrullus lanatus (Watermelon) on Blood Glucose Level and Lipid Profile of Diabetic Wistar Rats

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dc.contributor.authorFrancis, Deborahen_US
dc.contributor.authorAni, Celestineen_US
dc.contributor.authorNworgu, Choiceen_US
dc.contributor.authorPamela, Okorieen_US
dc.contributor.authorUzoma, Igween_US
dc.contributor.authorUzoigwe, Jideen_US
dc.contributor.authorUgwu, Princewillen_US
dc.contributor.authorAnyaeji, Pamelaen_US
dc.contributor.authorDaniel, Nwachukwuen_US
dc.date.accessioned2020-01-02T06:14:20Z
dc.date.available2020-01-02T06:14:20Z
dc.date.issued2019-03
dc.description.abstractAims: This study investigated the effect of ethanolic seed extract of Citrullus lanatus (ESECL) on blood glucose level and lipid profile in Alloxan-induced diabetic male Wistar rats. Study Design and Methodology: 30 male adult wistar rats were grouped randomly into six experimental groups of five rats each. Diabetes was induced by intraperitoneal injection of 100 mg/kg of alloxan monohydrate, dissolved in normal saline, while the normal control group (group 1) was given the vehicle only. Three days after induction of diabetes, were treated further for four weeks with ESECL at doses of 100, 200 and 400 mg/kg for groups 4, 5, and 6 respectively. Animals in Group 3 were treated with Glibenclamide (2.5 mg/kg), while group 2 served as the negative control group. Results: Administration of ESECL caused significant decrease in blood glucose levels in groups 4, 5 and 6 compared to rats of group 2 (p=0.00125). There was also significant decrease in the levels of cholesterol (TC) , triglycerides (TG), low density lipoprotein (LDL), with increase in high density lipoprotein (HDL) in Groups 4, 5 and 6, compared to Group 2 rats (p=0.00125). The results obtained from the rats of the group receiving extract were similar to that obtained from Groups 3. Conclusion: Thus, this study suggests that this extract could possibly normalize abnormalities in blood glucose levels and lipid profiles in diabetic conditions in a dose dependent manner.en_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.en_US
dc.identifier.affiliationsDepartment of Human Physiology, College of Medicine, Enugu State University of Science & Technology, Parklane, Enugu, Nigeriaen_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeriaen_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeriaen_US
dc.identifier.affiliationsDepartment of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeriaen_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.en_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeriaen_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeriaen_US
dc.identifier.citationFrancis Deborah, Ani Celestine, Nworgu Choice, Pamela Okorie, Uzoma Igwe, Uzoigwe Jide, Ugwu Princewill, Anyaeji Pamela, Daniel Nwachukwu. The Effect of Ethanolic Seed Extract of Citrullus lanatus (Watermelon) on Blood Glucose Level and Lipid Profile of Diabetic Wistar Rats. European Journal of Medicinal Plants. 2019 Mar; 26(4): 1-6en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189447
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume26en_US
dc.source.urinullen_US
dc.subjectDiabetesen_US
dc.subjectCitrullus lanatusen_US
dc.subjectfasting sugar levelen_US
dc.subjecthypolipidaemic and phytochemicalen_US
dc.titleThe Effect of Ethanolic Seed Extract of Citrullus lanatus (Watermelon) on Blood Glucose Level and Lipid Profile of Diabetic Wistar Ratsen_US
dc.typeJournal Articleen_US
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