Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases.

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dc.contributor.authorPhadke, R Sen_US
dc.contributor.authorVaideeswar, Pen_US
dc.contributor.authorMittal, Ben_US
dc.contributor.authorDeshpande, Jen_US
dc.date.accessioned2001-07-08en_US
dc.date.accessioned2009-06-02T13:40:22Z
dc.date.available2001-07-08en_US
dc.date.available2009-06-02T13:40:22Z
dc.date.issued2001-07-08en_US
dc.description.abstractBACKGROUND: Hypertrophic cardiomyopathy (HCM) is one of the less common forms of primary cardiomyopathies. There is little data available on HCM in Indian literature. AIMS: To assess the incidence and analyse the clinicopathological features of HCM. SETTINGS: Analysis of data of 15 years from a tertiary care centre. METHODS AND MATERIAL: The clinical and pathological data in fourteen cases of HCM with respect to their gross and microscopic features and clinical presentation were reviewed. RESULTS: Incidence of HCM amongst the autopsied primary cardiomyopathies (N = 101) was 13.9% (n=14). Males were affected more. Common presenting symptoms were exertional dyspnoea, angina and palpitations. Concentric and asymmetric hypertrophy was equally seen. Obliterative small vessel disease was noted in 50% of the cases. Although significant myofibre disarray (>5%) was seen in all fourteen cases, it could be demonstrated in only 40- 50% of an average of twenty sections studied. Type IA myofibre disarray was the commonest. Six of the fourteen patients died suddenly. Cardiac failure was the commonest cause of death. CONCLUSIONS: Myofibre disarray is a highly sensitive and specific marker for HCM only when considered in a quantitative rather than a qualitative fashion. In this context, the rationale for performing endomyocardial biopsy is to rule out mimics of HCM.en_US
dc.description.affiliationDepartment of Pathology, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India. phrahul25@hotmail.comen_US
dc.identifier.citationPhadke RS, Vaideeswar P, Mittal B, Deshpande J. Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases. Journal of Postgraduate Medicine. 2001 Jul-Sep; 47(3): 165-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/117762
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAutopsyen_US
dc.subject.meshCardiomyopathy, Hypertrophic --complicationsen_US
dc.subject.meshDeath, Sudden, Cardiac --etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardium --pathologyen_US
dc.subject.meshMyofibrils --pathologyen_US
dc.subject.meshOrgan Sizeen_US
dc.titleHypertrophic cardiomyopathy: an autopsy analysis of 14 cases.en_US
dc.typeJournal Articleen_US
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