Liver pathology in collagen vascular disorders highlighting the vascular changes within portal tracts.

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dc.contributor.authorVaiphei, Kim
dc.contributor.authorBhatia, Alka
dc.contributor.authorSinha, Saroj Kant
dc.date.accessioned2012-10-01T10:32:01Z
dc.date.available2012-10-01T10:32:01Z
dc.date.issued2011-01
dc.description.abstractBackground: Collagen vascular disorders (CVDs) are autoimmune disorders with multisystem involvement. Clinical liver involvement is not a characteristic feature though histological involvement could be frequent. Liver disease in CVDs could be the consequence of various factors. Aim: The aim was to analyze the histological spectrum of liver in collagen vascular disorders (CVDs) at autopsy. Materials and Methods: Thirty-six autopsy livers negative for hepatitis B or C virus were studied in CVD cases with no known association with chronic liver disease or vascular thrombosis or hematological disorder. Cirrhotic and normal livers were used as controls. The paired t-test, one-way ANOVA, and two-sided Dunnett t-test were used for comparison (< 0.05). None of the control cases showed any abnormal vessels. Results: There were 21 systemic lupus erythematosus (SLE), 7 rheumatoid arthritis (RA), 5 systemic sclerosis (SSc), and 3 polyarteritis nodosa (PAN) cases (M:F = 11:25, age range 23-60 years). Histology: Diffuse nodular regenerative hyperplasia of liver (NRHL) was seen in 10 cases, and 6 (5 SLE and 1 RA) had numerous abnormal thin-walled vessels in intermediate- and small-sized portal tracts with no vascular occlusion or inflammation. Moderate sized portal tracts showed more interface and lobular inflammation. The main portal vein and its major branches were normal. None of these six cases had increased transmainases (P>0.05). Most SLE cases had increased transaminases (P<0.05). No evidence of portal hypertension was seen in all except in one RA. Septicemia is known to be associated with raised transaminases. Conclusion: A rare pathology of conglomerate of abnormal vessels in intermediate- and small-sized portal system was observed co-existing with NRHL in CVDs. Raised liver enzyme with interface hepatitis in CVD may not necessarily warrant an overlap, as a similar feature could be observed in septicemia.en_US
dc.identifier.citationVaiphei Kim, Bhatia Alka, Sinha Saroj Kant. Liver pathology in collagen vascular disorders highlighting the vascular changes within portal tracts. Indian Journal of Pathology & Microbiology. 2011 Jan-Mar 54(1): 25-31.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/141910
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=25;epage=31;aulast=Vaipheien_US
dc.subjectAutoimmune hepatitisen_US
dc.subjectcollagen vascular disordersen_US
dc.subjectnodular regenerative hyperplasia of liveren_US
dc.subjectportal hypertensionen_US
dc.subjectportal veinen_US
dc.subject.meshAdult
dc.subject.meshAutopsy
dc.subject.meshCollagen Diseases --complications
dc.subject.meshCollagen Diseases --pathology
dc.subject.meshFemale
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshLiver --blood supply
dc.subject.meshLiver --pathology
dc.subject.meshLiver Diseases --pathology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPortal Vein --pathology
dc.subject.meshVascular Diseases --complications
dc.subject.meshVascular Diseases --pathology
dc.titleLiver pathology in collagen vascular disorders highlighting the vascular changes within portal tracts.en_US
dc.typeArticleen_US
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