Screening and Identification of Fibrinolytic Bacteria from Malaysian Fermented Seafood Products.

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dc.contributor.authorZakaria, Zarita
dc.contributor.authorSalleh, Madihah Mohd.
dc.contributor.authorRashid, Noor Aini Abdul
dc.date.accessioned2015-11-30T05:33:12Z
dc.date.available2015-11-30T05:33:12Z
dc.date.issued2015-10
dc.description.abstractNatural fibrinolytic enzymes have been focused recently when compared to chemically synthesize thrombolytic drugs as they are more economical and believe to have less adverse reaction. Belacan (shrimp paste), Budu (fish sauce) and Cencaluk (shrimp sauce) were traditional fermented Malay seafood products used as sources for this study. The isolation and screening resulted in the discovery of 43 potential isolates with the ability as an extracellular fibrin degrader. Each isolate were unique due to differences in morphology characteristics and the amounts of fibrinolytic enzyme secretes under standard growth condition. Furthermore, it has been demonstrated that some strains posses the ability to act as tissue plasminogen activator (t-PA) which in deed has beneficial to many medicinal and therapeutic purposes. Of these 43 strains investigated for the fibrinolytic enzyme production, three species, mainly the best producer from each food sample were chosen for further molecular identification. This lead to the discovery of B. cereus 13BN, B. subtilis 2CN and B. subtilis 9BD strains, which posses both high fibrinolytic and t-PA activities, making it extremely valuable and promising producer.en_US
dc.identifier.citationZakaria Zarita, Salleh Madihah Mohd, Rashid Noor Aini Abdul. Screening and Identification of Fibrinolytic Bacteria from Malaysian Fermented Seafood Products. Journal of Applied Pharmaceutical Science. 2015 Oct; 5(10): 22-31.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/166549
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=1647en_US
dc.subjectfibrinolytic enzymeen_US
dc.subjectextracellularen_US
dc.subjectt-PAen_US
dc.subjectBacillusen_US
dc.titleScreening and Identification of Fibrinolytic Bacteria from Malaysian Fermented Seafood Products.en_US
dc.typeArticleen_US
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